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Journal of Clinical and Investigative Surgery
Academic Journal Academic Journal | 26/11/2017 Please log in to see more details
Journal of Clinical and Investigative Surgery
26/11/2017

Subject terms:

clinical surgery - investigative surgery - surgery - Medicine

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Directory of Open Access Journals

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Indocyanine green enhanced surgery; principle, clinical applications and future research directions
Catalin Alius;Sorin Oprescu;Cristian Balalau;Adriana Elena Nica
Academic Journal Academic Journal | Journal of Clinical and Investigative Surgery, Vol 3, Iss 1, Pp 1-8 (2018) Please log in to see more details
Over the past decade a new emergent technology has become very popular in all fields o... more
Indocyanine green enhanced surgery; principle, clinical applications and future research directions
Journal of Clinical and Investigative Surgery, Vol 3, Iss 1, Pp 1-8 (2018)
Over the past decade a new emergent technology has become very popular in all fields of surgery using Indocyanine green and near infrared fluorescent optical systems. This revolutionary approach overlaps conventional and near infrared images to produce highly informative intraoperative images on the anatomy and physiology of various tissues. Near infrared fluorescence is employed for perioperative angiography in vascular mapping, assessment of anastomoses, location of sentinel lymph nodes and delineation of biliary tree anatomy, highlighting tumours and metastatic deposits, improving surgical techniques and for many other uses. A lot of researchers have reported better surgical outcomes and technique innovations facilitated by this novel technology which although in its early stages, it lights up great interest worldwide. This article reviews the principle of the method, the properties of the fluorescent dye, the main clinical applications and discusses future research directions.

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indocyanine green - surgery - near infrared fluorescence - Medicine

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Directory of Open Access Journals

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Comparison of gingival blood flow during healing of simplified papilla preservation and modified widman flap surgery : a clinical trial using laser dopplerflowmetry
RETZEPI, M;TONETTI, M;DONOS, N
Academic Journal Academic Journal | Journal of clinical periodontology. 34(10):903-911 Please log in to see more details
Aim: This prospective randomized-controlled clinical trial compared the gingival blood... more
Comparison of gingival blood flow during healing of simplified papilla preservation and modified widman flap surgery : a clinical trial using laser dopplerflowmetry
Journal of clinical periodontology. 34(10):903-911
Aim: This prospective randomized-controlled clinical trial compared the gingival blood flow responses following simplified papilla preservation (test) versus modified Widman flap (control). Materials and Methods: Twenty contra-lateral upper sites with pocket depth ≥ 5 mm after initial treatment in 10 chronic periodontitis patients were randomly assigned to either test or control treatment, using a split-mouth design. Laser Doppler flowmetry recordings were performed pre-operatively, following anaesthesia, immediately post-operatively and on days 1, 2, 3, 4, 7, 15, 30 and 60, at nine selected sites per flap. Results: Significant ischaemia was observed at all sites following anaesthesia and immediately post-operatively. At the mucosal flap basis, a peak hyperaemic response was observed on day 1, which tended to resolve by day 4 at the test sites, but persisted until day 7 at the control sites. The buccal and palatal papillae blood perfusion presented the maximum increase on day 7 in both groups and returned to baseline by day 15. Both surgical modalities yielded significant pocket depth reduction, recession increase and clinical attachment gain. Conclusions: Periodontal access flaps represent an ischaemia-reperfusion flap model. The simplified papilla preservation flap may be associated with faster recovery of the gingival blood flow post-operatively compared with the modified Widman flap.

Subject terms:

Otorhinolaryngology, stomatology, dentistry - Otorhinolaryngologie, stomatologie, dentisterie - Sciences biologiques et medicales - Biological and medical sciences - Sciences medicales - Medical sciences - Techniques d'exploration et de diagnostic (generalites) - Investigative techniques, diagnostic techniques (general aspects) - Exploration par ultrasons - Ultrasonic investigative techniques - Coeur et vaisseaux - Cardiovascular system - Chirurgie - Surgery - Cirugía - Accessibilité - Accessibility - Accesibilidad - Cicatrisant - Healing agent - Cicatrizante - Cicatrisation - Cicatrization - Cicatrización - Conservation - Conservación - Dentisterie - Dentistry - Odontología - Dopplérométrie laser - Laser dopplerometry - Dopplerometría laser - Débit sanguin - Blood flow - Flujo sanguíneo - Débitmétrie - Flowmetry - Caudalimetría - Essai clinique - Clinical trial - Ensayo clínico - Etude comparative - Comparative study - Estudio comparativo - Gencive - Gingiva - Encía - Lambeau - Flap (surgery) - Colgajo - Laser - Láser - Plaie - Wound - Herida - Préservation - Preservation - Preservación - Traitement - Treatment - Tratamiento - blood flow - laser Doppler flowmetry - periodontal access flap - wound healing

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PASCAL Archive

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An Examination of the Usefulness of Repeat Testing Practices in a Large Hospital Clinical Chemistry Laboratory
DEETZ, Carl O;NOLAN, Debra K;SCOTT, Mitchell G
Academic Journal Academic Journal | American journal of clinical pathology. 137(1):20-25 Please log in to see more details
A long-standing practice in clinical laboratories has been to automatically repeat lab... more
An Examination of the Usefulness of Repeat Testing Practices in a Large Hospital Clinical Chemistry Laboratory
American journal of clinical pathology. 137(1):20-25
A long-standing practice in clinical laboratories has been to automatically repeat laboratory tests when values trigger automated repeat rules in the laboratory information system such as a critical test result. We examined 25,553 repeated laboratory values for 30 common chemistry tests from December 1, 2010, to February 28, 2011, to determine whether this practice is necessary and whether it may be possible to reduce repeat testing to improve efficiency and turnaround time for reporting critical values. An error was defined to occur when the difference between the initial and verified values exceeded the College of American Pathologists/Clinical Laboratory Improvement Amendments allowable error limit. The initial values from 2.6% of all repeated tests (668) were errors. Of these 668 errors, only 102 occurred for values within the analytic measurement range. Median delays in reporting critical values owing to repeated testing ranged from 5 (blood gases) to 17 (glucose) minutes.

Subject terms:

Medical oncology - Cancérologie - Medical laboratory techniques - Techniques de laboratoire médical - General medicine general surgery - Médecine et chirurgie générales - Sciences biologiques et medicales - Biological and medical sciences - Sciences medicales - Medical sciences - Techniques d'exploration et de diagnostic (generalites) - Investigative techniques, diagnostic techniques (general aspects) - Anatomopathologie. Exploration cytologique. Biochimie. Spectrométries. Méthodes cliniques et paracliniques diverses - Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques - Anatomopathologie - Anatomic pathology - Anatomía patológica - Biologie clinique - Clinical biology - Biología clínica - Conduite à tenir - Clinical management - Actitud médica - Dépistage - Medical screening - Descubrimiento - Erreur - Error - Hôpital - Hospital - Laboratoire - Laboratory - Laboratorio - Pratique professionnelle - Professional practice - Práctica profesional - Valeur critique - Critical value - Valor crítico - Laboratory error - Laboratory management

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Stuck Between a Scalpel and a Rock, or Molecular Pathology and Legal-Ethical Issues in Use of Tissues for Clinical Care and Research: What Must a Pathologist Know?
DRY, Sarah;GRODY, Wayne W;PAPAGNI, Paul
Academic Journal Academic Journal | American journal of clinical pathology. 137(3):346-355 Please log in to see more details
Personalized medicine and health care reform offer the opportunity for pathologists to... more
Stuck Between a Scalpel and a Rock, or Molecular Pathology and Legal-Ethical Issues in Use of Tissues for Clinical Care and Research: What Must a Pathologist Know?
American journal of clinical pathology. 137(3):346-355
Personalized medicine and health care reform offer the opportunity for pathologists to have a more central and visible role in patient care. Pathologists face new and more complicated requests for clinical and research testing on tissue specimens, including testing for somatic and inherited mutations. Pathologists must comprehend the applications and requirements for molecular testing and their legal and ethical responsibilities in handling tissue requests for clinical and research purposes to best serve the needs of patients and clinicians and to comply with federal and state laws. This article reviews these rapidly evolving and complex areas.

Subject terms:

Medical oncology - Cancérologie - Medical laboratory techniques - Techniques de laboratoire médical - General medicine general surgery - Médecine et chirurgie générales - Sciences biologiques et medicales - Biological and medical sciences - Sciences medicales - Medical sciences - Techniques d'exploration et de diagnostic (generalites) - Investigative techniques, diagnostic techniques (general aspects) - Anatomopathologie. Exploration cytologique. Biochimie. Spectrométries. Méthodes cliniques et paracliniques diverses - Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques - Anatomopathologie - Anatomic pathology - Anatomía patológica - Aspect juridique - Legal aspect - Aspecto jurídico - Ethique - Ethics - Etica - Génétique - Genetics - Genética - Recherche clinique - Clinical research - Investigación clínica - Scalpel - Escalpelo - Soin - Care - Cuidado - Tissu - Tissue - Tejido - Utilisation - Use - Uso - Rho kinase - Ethical - Legal - Molecular pathology - Pathologist - Research - Tissues

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Human monocyte responses to lipopolysaccharide and 9-cis retinoic acid after laparoscopic surgery for colon cancer
KOLSETH, Ingrid B. M;FØRLAND, Dag T;RISØE, Petter K;FLOOD-KJELDSEN, Signe;A...
Academic Journal Academic Journal | Scandinavian journal of clinical & laboratory investigation. 72(8):593-601 Please log in to see more details
Surgery, even modern minimal invasive laparoscopic surgery, induces an initial inflamm... more
Human monocyte responses to lipopolysaccharide and 9-cis retinoic acid after laparoscopic surgery for colon cancer
Scandinavian journal of clinical & laboratory investigation. 72(8):593-601
Surgery, even modern minimal invasive laparoscopic surgery, induces an initial inflammatory and acute phase response which is followed by a period of immunosuppression rendering surgical patients more susceptible to infection. Here, we aimed to study changes in monocyte inflammatory responses and inflammatory modulation mechanisms following laparoscopic colorectal surgery for colon cancer. Blood samples were collected from 19 colon cancer patients before, directly after and daily for 3 days following surgery. Blood cells were exposed ex vivo to bacterial lipopolysaccharide (LPS) or the inflammatory modulator 9-cis retinoic acid (9cisRA). In blood samples taken prior to surgery, we found significant pro-inflammatory responses to LPS, indicating classical monocyte activation. Directly after surgery, LPS induced significantly less early pro-inflammatory cytokines and monocyte/granulocyte-attracting chemokines.The LPS-mediated release of interleukin (IL)-1β was still significantly attenuated 3 days after surgery. In patient monocytes collected after surgery, we found increased levels of suppressors of cytokine signaling (SOCS) 1 and SOCS3 mRNA, reported to be associated with polarization towards resolving macrophages. The retinoic acid isomer 9cisRA, reported to attenuate LPS-mediated inflammatory responses and alter chemokine responses in cultured monocytes, had a similar effect in patient blood. Three days after surgery, 9cisRA still attenuated pro-inflammatory responses, but the induction of monocyte chemoattractive protein (MCP)-1/CCL2 mRNA in monocytes was reduced. This study indicates changes in monocyte responses that last for at least 3 days after laparoscopic surgery.

Subject terms:

Medical laboratory techniques - Techniques de laboratoire médical - Sciences biologiques et medicales - Biological and medical sciences - Sciences medicales - Medical sciences - Gastroenterologie. Foie. Pancreas. Abdomen - Gastroenterology. Liver. Pancreas. Abdomen - Estomac. Duodénum. Intestin grêle. Côlon. Rectum. Anus - Stomach. Duodenum. Small intestine. Colon. Rectum. Anus - Tumeurs - Tumors - Techniques d'exploration et de diagnostic (generalites) - Investigative techniques, diagnostic techniques (general aspects) - Chirurgie (generalites). Transplantations, greffes d'organes et de tissus. Pathologie des greffons - Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases - Chirurgie de l'appareil digestif - Surgery of the digestive system - Cancer - Cáncer - Pathologie de l'appareil digestif - Digestive diseases - Aparato digestivo patología - Pathologie de l'estomac - Gastric disease - Estómago patología - Pathologie de l'intestin - Intestinal disease - Intestino patología - Pathologie du côlon - Colonic disease - Colón patología - Tumeur maligne - Malignant tumor - Tumor maligno - Alitrétinoïne - Alitretinoin - Alitretinoína - Anticancéreux - Antineoplastic agent - Anticanceroso - Biologie clinique - Clinical biology - Biología clínica - Cancer du côlon - Colon cancer - Cáncer del colon - Chimiokine - Chemokine - Quimioquina - Chirurgie endoscopique - Endoscopic surgery - Cirugía endoscópica - Coeliochirurgie - Laparoscopic surgery - Cirugía laparoscopica - Cytokine - Citoquina - Homme - Human - Hombre - Lipopolyoside - Lipopolysaccharide - Lipopoliósido - Monocyte - Monocito - Protéine SOCS - Suppressor of cytokine signalling - proteínas supresoras de la señalización por citocinas - Traitement - Treatment - Tratamiento - Cancer gastrointestinal - Gastrointestinal cancer - Cáncer gastrointestinal - Chirurgie digestive - Cytokines - chemokines - gastrointestinal cancer surgery - monocytes - suppressor of cytokine signaling

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Progastrin-Releasing Peptide Is a Candidate Marker for Quality Control in Clinical Sample Processing and Storage
KIM, Shine-Young;KIM, Ji-Su;HWANG, Sang-Hyun;PARK, Hye-Kyung;LEE, Jin-Hyeon...
Academic Journal Academic Journal | American journal of clinical pathology. 137(2):277-282 Please log in to see more details
For clinical epidemiologic and proteomic studies, the control of preanalytic variation... more
Progastrin-Releasing Peptide Is a Candidate Marker for Quality Control in Clinical Sample Processing and Storage
American journal of clinical pathology. 137(2):277-282
For clinical epidemiologic and proteomic studies, the control of preanalytic variation, including sample processing and storage, is important. We evaluated the stability of progastrin-releasing peptide (ProGRP) as a marker for the quality control of stored serum and plasma samples. The ProGRP from 23 healthy volunteers was measured serially for 8 hours at room temperature, and the results were validated with clinical samples from the biobank. A significant difference in ΔProGRP was also noted between good-quality (time delay <4 hours before storage) and poor-quality (time delay ≥4 hours before storage) specimens (mean ± SD, 0.17 ± 0. 08 vs 0.36 ± 0.14; P < .001; Wilcoxon signed-rank test). With a ΔProGRP cutoff of 0.22, the sensitivity and specificity of detection of the poor-quality samples were 85. 7% and 75.0%, respectively, in clinical validations. We demonstrated that ΔProGRP could be used as a marker for quality control in sample processing and storage in biobanks.

Subject terms:

Medical oncology - Cancérologie - Medical laboratory techniques - Techniques de laboratoire médical - General medicine general surgery - Médecine et chirurgie générales - Sciences biologiques et medicales - Biological and medical sciences - Sciences medicales - Medical sciences - Techniques d'exploration et de diagnostic (generalites) - Investigative techniques, diagnostic techniques (general aspects) - Anatomopathologie. Exploration cytologique. Biochimie. Spectrométries. Méthodes cliniques et paracliniques diverses - Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques - Anatomopathologie - Anatomic pathology - Anatomía patológica - Conservation - Conservación - Contrôle qualité - Quality control - Control de calidad - Dégradation - Degradation - Degradación - Indicateur biologique - Biological indicator - Indicador biológico - Isolat clinique - Clinical isolate - Aislado clinico - Marqueur biologique - Biological marker - Marcador biológico - Peptide - Peptides - Péptido - Protéomique - Proteomics - Proteómica - Stabilité - Stability - Estabilidad - Stockage - Storage - Almacenamiento - Biobank - Biomarker - ProGRP - Progastrin-releasing peptide - Rapid degradation - Sample stability

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PASCAL Archive

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Clinical and Pathologic Features of Secondary Acute Promyelocytic Leukemia
DUFFIELD, Amy S;AOKI, Joseph;LEVIS, Mark;COWAN, Kathleen;GOCKE, Christopher...
Academic Journal Academic Journal | American journal of clinical pathology. 137(3):395-402 Please log in to see more details
Acute promyelocytic leukemia (APL) is a relatively common form of acute myeloid leukem... more
Clinical and Pathologic Features of Secondary Acute Promyelocytic Leukemia
American journal of clinical pathology. 137(3):395-402
Acute promyelocytic leukemia (APL) is a relatively common form of acute myeloid leukemia (AML) that has an excellent prognosis. In contrast, secondary acute myeloid leukemias, including therapy-related AML and AML, with myelodysplasia-related changes, have a relatively poor prognosis. We identified 9 cases ofAPL at our institution in which there was a history of chemotherapy, radiotherapy, chronic immunosuppression, or antecedent myelodysplastic syndrome. The clinical and pathologic findings in these cases of secondary APL were compared with the clinical and pathologic findings in cases of de novo APL. We found that secondary and de novo APL had abnormal promyelocytes with similar morphologic and immunophenotypic features, comparable cytogenetic findings, comparable rates of FMS-like tyrosine kinase mutations, and similar rates of recurrent disease and death. These data suggest that secondary APL is similar to de novo APL and, thus, should be considered distinct from other secondary acute myeloid neoplasms.

Subject terms:

Medical oncology - Cancérologie - Medical laboratory techniques - Techniques de laboratoire médical - General medicine general surgery - Médecine et chirurgie générales - Sciences biologiques et medicales - Biological and medical sciences - Sciences medicales - Medical sciences - Hemopathies - Hematologic and hematopoietic diseases - Leucémies. Lymphomes malins. Réticuloses malignes. Hématodermies. Splénomégalie myéloïde - Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis - Techniques d'exploration et de diagnostic (generalites) - Investigative techniques, diagnostic techniques (general aspects) - Anatomopathologie. Exploration cytologique. Biochimie. Spectrométries. Méthodes cliniques et paracliniques diverses - Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques - Cancer - Cáncer - Hémopathie maligne - Malignant hemopathy - Hemopatía maligna - Aigu - Acute - Agudo - Anatomopathologie - Anatomic pathology - Anatomía patológica - Cytométrie flux - Flow cytometry - Citometría flujo - Forme clinique - Clinical form - Forma clínica - Leucémie aiguë myéloblastique - Acute myelogenous leukemia - Leucemia aguda mieloblástica - Leucémie myéloblastique M3 - M3 acute myelocytic leukemia - Leucemia mieloblástica M3 - Leucémie promyélocytaire - Promyelocytic leukemia - Leucemia promielocítica - Secondaire - Secondary - Secundario - Symptomatologie - Symptomatology - Sintomatología - Syndrome myélodysplasique - Myelodysplastic syndrome - Mielodisplastico síndrome - Syndrome myéloprolifératif - Myeloproliferative syndrome - Mieloproliferativo síndrome - Traitement - Treatment - Tratamiento - Hémopathie maligne myéloïde - Myeloid neoplasm - APL - Acute myeloid leukemia with myelodysplasia-related changes - Acute promyelocytic leukemia - Therapy-related acute myeloid leukemia - Therapy-related myeloid neoplasm

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External Quality Assurance Performance of Clinical Research Laboratories in Sub-Saharan Africa
AMUKELE, Timothy K;MICHAEL, Kurt;HANES, Mary;MILLER, Robert E;BROOKS JACKSO...
Academic Journal Academic Journal | American journal of clinical pathology. 138(5):720-723 Please log in to see more details
Patient Safety Monitoring in International Laboratories (JHU-SMILE) is a resource at J... more
External Quality Assurance Performance of Clinical Research Laboratories in Sub-Saharan Africa
American journal of clinical pathology. 138(5):720-723
Patient Safety Monitoring in International Laboratories (JHU-SMILE) is a resource at Johns Hopkins University that supports and monitors laboratories in National Institutes of Health―funded international clinical trials. To determine the impact of the JHU-SMILE quality assurance scheme in sub-Saharan African laboratories, we reviewed 40 to 60 months of external quality assurance (EQA) results of the College of American Pathologists (CAP) in these laboratories. We reviewed the performance of 8 analytes: albumin, alanine aminotransferase, creatinine, sodium, WBC, hemoglobin, hematocrit, and the human immunodeficiency virus antibody rapid test. Over the 40- to 60-month observation period, the sub-Saharan laboratories had a 1.63% failure rate, which was 40% lower than the 2011 CAP-wide rate of 2.8%. Seventy-six percent of the observed EQA failures occurred in 4 of the 21 laboratories. These results demonstrate that a system of remote monitoring, feedback, and audits can support quality in low-resource settings, even in places without strong regulatory support for laboratory quality.

Subject terms:

Afrique - Africa - Afrique subsaharienne - Sub-Saharan Africa - Africa subsahariana - Medical oncology - Cancérologie - Medical laboratory techniques - Techniques de laboratoire médical - General medicine general surgery - Médecine et chirurgie générales - Sciences biologiques et medicales - Biological and medical sciences - Sciences medicales - Medical sciences - Pathologie infectieuse - Infectious diseases - Viroses - Viral diseases - Viroses humaines - Human viral diseases - Viroses du tissu lymphoïde et du sang. Sida - Viral diseases of the lymphoid tissue and the blood. Aids - Immunopathologie - Immunopathology - Immunodéficits. Immunoglobulinopathies - Immunodeficiencies. Immunoglobulinopathies - Immunodéficits - Immunodeficiencies - Techniques d'exploration et de diagnostic (generalites) - Investigative techniques, diagnostic techniques (general aspects) - Anatomopathologie. Exploration cytologique. Biochimie. Spectrométries. Méthodes cliniques et paracliniques diverses - Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques - Immunodéficit - Immune deficiency - Inmunodeficiencia - Immunopathologie - Immunopathology - Inmunopatología - Infection - Infección - Lentivirus - Retroviridae - Virose - Viral disease - Virosis - Virus - Anatomopathologie - Anatomic pathology - Anatomía patológica - Assurance qualité - Quality assurance - Aseguración calidad - Evaluation performance - Performance evaluation - Evaluación prestación - Externe - External - Externo - Laboratoire - Laboratory - Laboratorio - Performance - Rendimiento - Recherche clinique - Clinical research - Investigación clínica - SIDA - AIDS - Virus immunodéficience humaine - Human immunodeficiency virus - CAP - HIV - PEPFAR - Sub-Saharan Africa

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Epidemiology of Escherichia coli, Klebsiella Species, and Proteus mirabilis Strains Producing Extended-Spectrum β-Lactamases From Clinical Samples in the Kinki Region of Japan
NAKAMURA, Tatsuya;KOMATSU, Masaru;SATOH, Kaori;TODA, Hirofumi;TOYOKAWA, Mas...
Academic Journal Academic Journal | American journal of clinical pathology. 137(4):620-626 Please log in to see more details
In the present study, nonduplicate, clinical isolates of extended-spectrum β-lactamase... more
Epidemiology of Escherichia coli, Klebsiella Species, and Proteus mirabilis Strains Producing Extended-Spectrum β-Lactamases From Clinical Samples in the Kinki Region of Japan
American journal of clinical pathology. 137(4):620-626
In the present study, nonduplicate, clinical isolates of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli, Klebsiella spp, and Proteus mirabilis were collected during a 10-year period from 2000 to 2009 at several hospitals in the Kinki region, Japan. The detection rate ofE coli markedly increased from 0.24% to 7.25%. The detection rate of Klebsiella pneumoniae increased from 0% to 2.44% and that of P mirabilisfrom 6.97% to 12.85%. The most frequently detected genotypes were the CTX-M9 group for E coli, the CTX-M2 group for K pneumoniae, and the CTX-M2 group for P mirabilis. E coli clone o25: H4-ST131 producing CTX-M-15, which is spreading worldwide, was first detected in 2007. The most common replicon type ofE coli was the IncF type, particularly FIB, detected in 466 strains (69. 7%). Of the K pneumoniae strains, 47 (55.3%) were of the IncN type; 77 P mirabilis strains (96.3%) were of the IncT type. In the future, the surveillance of various resistant bacteria, mainly ESBL-producing Enterobacteriaceae, should be expanded to prevent their spread.

Subject terms:

Asie - Asia - Japon - Japan - Japón - Medical oncology - Cancérologie - Medical laboratory techniques - Techniques de laboratoire médical - General medicine general surgery - Médecine et chirurgie générales - Sciences biologiques et medicales - Biological and medical sciences - Sciences medicales - Medical sciences - Techniques d'exploration et de diagnostic (generalites) - Investigative techniques, diagnostic techniques (general aspects) - Anatomopathologie. Exploration cytologique. Biochimie. Spectrométries. Méthodes cliniques et paracliniques diverses - Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques - Bactérie - Bacteria - Enterobacteriaceae - Anatomopathologie - Anatomic pathology - Anatomía patológica - Epidémiologie - Epidemiology - Epidemiología - Escherichia coli - Espèce - Species - Especie - Isolat clinique - Clinical isolate - Aislado clinico - Klebsiella - Proteus mirabilis - Réaction chaîne polymérase - Polymerase chain reaction - Reacción cadena polimerasa - Réplicon - Replicon - Replicón - Souche - Strain - Cepa - Surveillance - Vigilancia - β-Lactamase à spectre étendu - Extended-spectrum β-lactamase - β-lactamasa de espectro extendido - Extended-spectrum β-lactamases - Replicon type

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Determination of Turnaround Time in the Clinical Laboratory: Accessioning-to-Result Time Does Not Always Accurately Reflect Laboratory Performance
STOTLER, Brie A;KRATZ, Alexander
Academic Journal Academic Journal | American journal of clinical pathology. 138(5):724-729 Please log in to see more details
Laboratories often focus on computer-generated components of turnaround time (TAT) rep... more
Determination of Turnaround Time in the Clinical Laboratory: Accessioning-to-Result Time Does Not Always Accurately Reflect Laboratory Performance
American journal of clinical pathology. 138(5):724-729
Laboratories often focus on computer-generated components of turnaround time (TAT) reports that capture time from sample accessioning to reporting of results, and use this indicator to determine performance. This study assesses limitations of accessioning-to-results times and details ways in which to evaluate laboratory-controlled TAT. Samples were sent via pneumatic tube and times from arrival to accessioning were determined. Staffing was increased and the delay between sample arrival and accessioning was measured again. Significant delays were seen between specimen arrival and accessioning, which were not captured with computer-generated TAT reports. When TAT was calculated to include these delays, the TAT goal was not achieved. Increasing the number of employees significantly decreased delays. Laboratories must ensure that TAT reports encompass all laboratory-controlled parts of the testing processes. Analysis of causes for discrepancies between computer reports and clinician perceptions, combined with targeted measurements and well-designed interventions, can decrease TAT and improve service.

Subject terms:

Medical oncology - Cancérologie - Medical laboratory techniques - Techniques de laboratoire médical - General medicine general surgery - Médecine et chirurgie générales - Sciences biologiques et medicales - Biological and medical sciences - Sciences medicales - Medical sciences - Techniques d'exploration et de diagnostic (generalites) - Investigative techniques, diagnostic techniques (general aspects) - Anatomopathologie. Exploration cytologique. Biochimie. Spectrométries. Méthodes cliniques et paracliniques diverses - Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques - Anatomopathologie - Anatomic pathology - Anatomía patológica - Assurance qualité - Quality assurance - Aseguración calidad - Evaluation performance - Performance evaluation - Evaluación prestación - Laboratoire - Laboratory - Laboratorio - Performance - Rendimiento - Qualité - Quality - Calidad - Accessioning time - Clinical laboratory - Quality improvement - Turnaround time

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Clinical, Morphologic, Immunophenotypic, and Molecular Cytogenetic Assessment of CD4-/CD8- γδ T-Cell Large Granular Lymphocytic Leukemia
CHEN, Yi-Hua;CHADBURN, Amy;EVENS, Andrew M;WINTER, Jane N;GORDON, Leo I;CHE...
Academic Journal Academic Journal | American journal of clinical pathology. 136(2):289-299 Please log in to see more details
γδ T-cell large granular lymphocytic (T-LGL) leukemia of the CD4-/CD8- subtype is rare... more
Clinical, Morphologic, Immunophenotypic, and Molecular Cytogenetic Assessment of CD4-/CD8- γδ T-Cell Large Granular Lymphocytic Leukemia
American journal of clinical pathology. 136(2):289-299
γδ T-cell large granular lymphocytic (T-LGL) leukemia of the CD4-/CD8- subtype is rare, and data are limited in the literature. This study evaluated the clinical, morphologic, immunophenotypic, and molecular cytogenetic features of 7 cases of CD4-/ CD8- γδ T-LGL leukemia. Although this variant shares several clinical and morphologic features with the more common T-LGL leukemias, the incidences of autoimmune hemolytic anemia and pure red cell aplasia are higher. Another striking feature observed in our study was the lack of increased large granular lymphocytes in the peripheral blood in the majority of cases despite prominent bone marrow or splenic involvement. CD4-/CD8- γδ T-LGL leukemia also displays an immunophenotype and pattern of splenic involvement overlapping with hepatosplenic T-cell lymphoma. Clinically, this variant of T-LGL leukemia shows an overall indolent course, but treatment is often required in the initial stages of the disease. Awareness of these features is important for early recognition and accurate diagnosis of patients with CD4-/CD8- γδ T-LGL leukemia.

Subject terms:

Medical oncology - Cancérologie - Medical laboratory techniques - Techniques de laboratoire médical - General medicine general surgery - Médecine et chirurgie générales - Sciences biologiques et medicales - Biological and medical sciences - Sciences medicales - Medical sciences - Techniques d'exploration et de diagnostic (generalites) - Investigative techniques, diagnostic techniques (general aspects) - Anatomopathologie. Exploration cytologique. Biochimie. Spectrométries. Méthodes cliniques et paracliniques diverses - Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques - Anatomopathologie - Anatomic pathology - Anatomía patológica - Cytogénétique - Cytogenetics - Citogenética - Forme clinique - Clinical form - Forma clínica - Immunophénotype - Immunophenotype - Inmunofenotipo - Lymphocyte T CD4 - CD4 T lymphocyte - Linfocito T CD4 - Lymphocyte T CD8 - CD8 T lymphocyte - Linfocito T CD8 - Lymphocyte T - T-Lymphocyte - Linfocito T - Moelle osseuse - Bone marrow - Médula ósea - Morphologie - Morphology - Morfología - Rate - Spleen - Bazo - Récepteur cellule T γ/δ - γ/δ T cell receptor - Receptor célula T γ/δ - Symptomatologie - Symptomatology - Sintomatología - Hémopathie maligne lymphoïde - Lymphoid neoplasm - Clinical features - Morphologic features - γδ T-cell large granular lymphocytic leukemia

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What Proportion of Vancomycin Trough Levels Are Drawn Too Early?: Frequency and Impact on Clinical Actions
MORRISON, Aileen P;MELANSON, Stacy E. F;CARTY, Marcy G;BATES, David W;SZUMI...
Academic Journal Academic Journal | American journal of clinical pathology. 137(3):472-478 Please log in to see more details
Vancomycin trough levels are recommended to predict vancomycin efficacy, and inaccurat... more
What Proportion of Vancomycin Trough Levels Are Drawn Too Early?: Frequency and Impact on Clinical Actions
American journal of clinical pathology. 137(3):472-478
Vancomycin trough levels are recommended to predict vancomycin efficacy, and inaccurate levels may lead to inappropriate clinical actions. However, the frequency of timing errors and associated clinical impact is unknown. We retrospectively analyzed vancomycin levels (n = 2,597) measured during 13 months at a large academic medical center. Of the specimens, 41.3% were drawn too early. These samples yielded significantly higher average ± SD vancomycin concentrations than correctly timed samples (22.1 ± 11.7 mg/L vs 15.5 mg/L ± 8.6 mg/L; P < .001), and, consequently, clinicians were more likely to decrease, discontinue, or hold a patient's vancomycin dose (25.6% vs 21.4%; P < .02) or repeat the vancomycin level (29.2% vs 20.0%; P < .001). A substantial proportion of specimens collected to assess vancomycin efficacy were drawn too early, leading to overestimation ofpatients' true trough level and possible underdosing of vancomycin or a high rate of repeat tests for vancomycin.

Subject terms:

Medical oncology - Cancérologie - Medical laboratory techniques - Techniques de laboratoire médical - General medicine general surgery - Médecine et chirurgie générales - Sciences biologiques et medicales - Biological and medical sciences - Sciences medicales - Medical sciences - Techniques d'exploration et de diagnostic (generalites) - Investigative techniques, diagnostic techniques (general aspects) - Anatomopathologie. Exploration cytologique. Biochimie. Spectrométries. Méthodes cliniques et paracliniques diverses - Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques - Anatomopathologie - Anatomic pathology - Anatomía patológica - Fréquence - Frequency - Frecuencia - Homme - Human - Hombre - Proportion - Proporción - Précoce - Early - Precoz - Prélèvement - Samplings - Toma de muestra - Qualité - Quality - Calidad - Suivi thérapeutique pharmacologique - Therapeutic drug monitoring - Monitorización farmacoterapéutica - Toxicité - Toxicity - Toxicidad - Vancomycine - Vancomycin - Vancomicina - Patient safety - Specimen collection

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LBP and sCD14 patterns in total hip replacement surgery performed during combined spinal/epidural anaesthesia
BASTIAN, Daniel;TAMBURSTUEN, Margareth V;LYNGSTADAAS, Stale P;REIKERAS, Ola...
Academic Journal Academic Journal | Scandinavian journal of clinical & laboratory investigation. 71(6):486-491 Please log in to see more details
Background. Danger patterns and pattern recognition receptors have been targets in the... more
LBP and sCD14 patterns in total hip replacement surgery performed during combined spinal/epidural anaesthesia
Scandinavian journal of clinical & laboratory investigation. 71(6):486-491
Background. Danger patterns and pattern recognition receptors have been targets in the investigation and treatment of systemic inflammatory response syndrome and sepsis. Lipopolysaccharide (LPS)-binding protein (LBP) presents LPS and gram-positive bacterial cell wall products to the receptors TLR4/MD-2 andTLR2, respectively. Low concentrations of LBP stimulate responses to LPS and peptidoglycan, whereas higher concentrations inhibit these responses. Soluble CD14 (sCD14) presents the LBP-LPS complex to CD14-negative cells, and it modulates the biological activity of circulating LPS. In this study, we aimed to elucidate the physiological reactions to LBP and sCD14 after total hip replacement surgery during spinal/epidural anaesthesia. Methods. Seven patients with coxarthrosis were operated upon with a total hip replacement, which is a defined trauma to bone and muscles in conjunction with a certain amount of blood loss. Venous blood samples were taken before the operation and at 1 h, 3 days and 6 days after surgery. LBP and sCD14 were measured by conventional ELISA. To correct for hemodilution, each parameter was adjusted for hematocrit. A panel of cytokines was measured using Luminex technology to evaluate the trauma reaction. Results. IL-6 levels peaked 24 h after the operation, whereas IL-1β and IL-10 levels remained unchanged. Systemic levels of LBP were increased 24 h after surgery, whereas sCD14 remained steady. However, the dilution-corrected sCD14 values increased significantly, and the levels of both LBP and sCD14 peaked at day 3 after surgery. Conclusion. Aseptic trauma primes the innate immune system for the posttraumatic release of LBP and sCD14.

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Medical laboratory techniques - Techniques de laboratoire médical - Sciences biologiques et medicales - Biological and medical sciences - Sciences medicales - Medical sciences - Techniques d'exploration et de diagnostic (generalites) - Investigative techniques, diagnostic techniques (general aspects) - Chirurgie (generalites). Transplantations, greffes d'organes et de tissus. Pathologie des greffons - Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases - Chirurgie orthopédique - Orthopedic surgery - Biologie clinique - Clinical biology - Biología clínica - Chirurgie orthopédique - Orthopedic surgery - Cirugía ortopédica - Extradural - Forme soluble - Soluble form - Forma soluble - Lipopolyoside - Lipopolysaccharide - Lipopoliósido - Protéine liaison - Binding protein - Proteína enlace - Traitement - Treatment - Tratamiento - Traumatisme - Trauma - Traumatismo - Antigène CD14 - Prothèse de hanche - Hip prosthesis - Prótesis de cadera - Lipopolysaccharide-binding protein - hip prosthesis - soluble CD14 - surgery - trauma

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A New PCR-Based Mass Spectrometry System for High-Risk HPV, Part II: Clinical Trial
HUI DU;JI YI;RUIFANG WU;BELINSON, Suzanne E;XINFENG QU;BIN YANG;CHUN WANG;X...
Academic Journal Academic Journal | American journal of clinical pathology. 136(6):920-923 Please log in to see more details
This was a population-based clinical trial of a polymerase chain reaction―based multip... more
A New PCR-Based Mass Spectrometry System for High-Risk HPV, Part II: Clinical Trial
American journal of clinical pathology. 136(6):920-923
This was a population-based clinical trial of a polymerase chain reaction―based multiplex high-risk human papillomavirus (HR-HPV) assay using mass spectrometry (MassARRAY [Sequenom, San Diego, CA] matrix-assisted laser desorption/ionization time-of-flight mass spectrometry system [MALDI-TOF]). Participants were 10, 000 women between the ages of 25 and 59 years in Guangdong Province, China (SHENCCAST II Study). All women collected a self-sample (tested with Cervista [Hologic, Marlborough, MA] and MALDI-TOF) followed by a clinician-collected cervical sample (for cytology, Hybrid Capture 2 [HC2; Qiagen, Gaithersburg, MD], Cervista, and MALDI-TOF). Patients with any abnormal result were asked to return for colposcopy and biopsies. This analysis included the data for 8,556 women. The sensitivity values for cervical intraepithelial neoplasia (CIN) 3 or worse for a direct cervical sample were 97.9%, 95.1%, and 94.3 for HC2, Cervista, and MALDI-TOF, respectively (P > .05). The sensitivity for CIN 3 or worse for a self-collected sample tested with MALDI-TOF was also 94.3%, which was similar to a clinician-obtained endocervical sample assayed with the 3 HR-HPTI assays. MALDI-TOF combined with a self-collected sample provides a highly sensitive, high-throughput, low-cost-per-case assay for mass screening.

Subject terms:

Medical oncology - Cancérologie - Medical laboratory techniques - Techniques de laboratoire médical - General medicine general surgery - Médecine et chirurgie générales - Sciences biologiques et medicales - Biological and medical sciences - Sciences medicales - Medical sciences - Pathologie infectieuse - Infectious diseases - Viroses - Viral diseases - Gynecologie. Andrologie. Obstetrique - Gynecology. Andrology. Obstetrics - Pathologie de l'appareil génital femelle - Female genital diseases - Tumeurs - Tumors - Techniques d'exploration et de diagnostic (generalites) - Investigative techniques, diagnostic techniques (general aspects) - Anatomopathologie. Exploration cytologique. Biochimie. Spectrométries. Méthodes cliniques et paracliniques diverses - Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques - Cancer - Cáncer - Infection - Infección - Papillomavirus - Papovaviridae - Pathologie de l'appareil génital femelle - Female genital diseases - Aparato genital hembra patología - Pathologie du col de l'utérus - Uterine cervix diseases - Cuello útero patología - Tumeur maligne - Malignant tumor - Tumor maligno - Virus - Anatomopathologie - Anatomic pathology - Anatomía patológica - Cancer du col de l'utérus - Cervical cancer - Cáncer de cuello del útero - Dépistage - Medical screening - Descubrimiento - Désorption laser - Laser desorption - Desorción láser - Essai clinique - Clinical trial - Ensayo clínico - Ionisation - Ionization - Ionización - Méthode temps vol - Time of flight method - Método tiempo vuelo - Papillomavirus humain - Human papillomavirus - Risque élevé - High risk - Riesgo alto - Réaction chaîne polymérase - Polymerase chain reaction - Reacción cadena polimerasa - Spectrométrie masse - Mass spectrometry - Espectrometría masa - Virose - Viral disease - Virosis - HPV - MALDI-TOF - Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry system - Screening

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The Liver in Celiac Disease: Clinical Manifestations, Histologic Features, and Response to Gluten-Free Diet in 30 Patients
MOUNAJJED, Taofic;OXENTENKO, Amy;SHMIDT, Eugenia;SMYRK, Thomas
Academic Journal Academic Journal | American journal of clinical pathology. 136(1):128-137 Please log in to see more details
Descriptive reports of liver histologic features in celiac disease (CD) are sparse, an... more
The Liver in Celiac Disease: Clinical Manifestations, Histologic Features, and Response to Gluten-Free Diet in 30 Patients
American journal of clinical pathology. 136(1):128-137
Descriptive reports of liver histologic features in celiac disease (CD) are sparse, and the effect of a gluten-free diet (GFD) on the course of liver injury is poorly understood. We reviewed liver biopsy specimens in 30 patients with CD and performed immunostains for IgG, IgG4, IgM, and IgA. Subsequent liver biochemical tests and compliance with the GFD were recorded. Of the patients, 19 had autoimmune-mediated liver disease (AILD; autoimmune hepatitis, 9; primary sclerosing cholangitis, 7; and primary biliary cirrhosis, 3). The remaining 11 patients had cryptogenic hepatitis (5), hepatitis C (2), steatohepatitis (2), sarcoidosis (1), and T-cell lymphoma (1). The liver disease diagnosis preceded the CD diagnosis in all groups except steatohepatitis. Although 82% ofpatients without AILD had symptomatic CD, only 26% ofpatients with AILD had such symptoms. The pathology of the specific liver disease was not atypical in histologic features or IgG/ IgM ratios. While GFD improved cryptogenic hepatitis, it did not seem to affect AILD. We propose that AILD and cryptogenic hepatitis in patients with CD represent distinct clinical, histologic, and immunohistochemical entities rather than 2 ends of a spectrum of liver injury.

Subject terms:

Medical oncology - Cancérologie - Medical laboratory techniques - Techniques de laboratoire médical - General medicine general surgery - Médecine et chirurgie générales - Sciences biologiques et medicales - Biological and medical sciences - Sciences medicales - Medical sciences - Gastroenterologie. Foie. Pancreas. Abdomen - Gastroenterology. Liver. Pancreas. Abdomen - Estomac. Duodénum. Intestin grêle. Côlon. Rectum. Anus - Stomach. Duodenum. Small intestine. Colon. Rectum. Anus - Autres maladies. Sémiologie - Other diseases. Semiology - Foie. Voies biliaires. Circulation portale. Pancréas exocrine - Liver. Biliary tract. Portal circulation. Exocrine pancreas - Techniques d'exploration et de diagnostic (generalites) - Investigative techniques, diagnostic techniques (general aspects) - Anatomopathologie. Exploration cytologique. Biochimie. Spectrométries. Méthodes cliniques et paracliniques diverses - Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques - Alimentation - Feeding - Alimentación - Immunopathologie - Immunopathology - Inmunopatología - Malabsorption intestinale - Intestinal malabsorption - Malabsorción intestinal - Pathologie de l'appareil digestif - Digestive diseases - Aparato digestivo patología - Pathologie de l'intestin - Intestinal disease - Intestino patología - Pathologie des voies biliaires - Biliary tract disease - Vía biliar patología - Anatomopathologie - Anatomic pathology - Anatomía patológica - Angiocholite sténosante - Sclerosing cholangitis - Angiocolitis estenosante - Cirrhose biliaire primitive - Primary biliary cirrhosis - Cirrosis biliar primaria - Forme clinique - Clinical form - Forma clínica - Histologie - Histology - Histología - Homme - Human - Hombre - Hépatite - Hepatitis - Maladie autoimmune - Autoimmune disease - Enfermedad autoinmune - Maladie coeliaque - Coeliac disease - Enfermedad celíaca - Pathologie du foie - Hepatic disease - Hígado patología - Primaire - Primary - Primario - Régime alimentaire dépourvu - Deficient diet - Régimen alimenticio deficiente - Symptomatologie - Symptomatology - Sintomatología - Autoimmune hepatitis - Autoimmune-mediated liver disease - Celiac disease - Gluten-free diet - Liver diseases - Primary sclerosing cholangitis

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The Spectrum of Hematologic Malignancies Involving the Pancreas: Potential Clinical Mimics of Pancreatic Adenocarcinoma
ROCK, Jonathan;BLOOMSTON, Mark;LOZANSKI, Gerard;FRANKEL, Wendy L
Academic Journal Academic Journal | American journal of clinical pathology. 137(3):414-422 Please log in to see more details
Hematologic malignancies often involve the pancreas, causing potential diagnostic pitf... more
The Spectrum of Hematologic Malignancies Involving the Pancreas: Potential Clinical Mimics of Pancreatic Adenocarcinoma
American journal of clinical pathology. 137(3):414-422
Hematologic malignancies often involve the pancreas, causing potential diagnostic pitfalls and, rarely, potentially avoidable surgical resection. We review the spectrum of hematologic malignancies involving the pancreas and describe features useful in preoperative distinction from adenocarcinoma. Archived clinical, pathologic, and radiologic data (1965 to present) for hematologic malignancies involving the pancreas were reviewed and compared with the data for 157 surgically resected pancreatic adenocarcinomas. Of 42 cases, 27 (64%) were clinically suspicious for hematologic malignancies. Of the remaining 15 cases, 4 patients underwent resection for presumed pancreatic adenocarcinoma. Isolated pancreatic masses proved most difficult to identify clinically. Significant factors in distinguishing hematologic malignancies from adenocarcinoma included history of hematologic malignancy, young age, large tumor size, low CA19-9 level, B symptoms, and lack ofjaundice or diabetes mellitus. Various hematologic malignancies involve the pancreas, most commonly diffuse large B-cell lymphoma. Pancreatic masses are usually correctly identified clinically. Preoperative and operative sampling is strongly recommended when hematologic malignancies cannot be excluded.

Subject terms:

Medical oncology - Cancérologie - Medical laboratory techniques - Techniques de laboratoire médical - General medicine general surgery - Médecine et chirurgie générales - Sciences biologiques et medicales - Biological and medical sciences - Sciences medicales - Medical sciences - Gastroenterologie. Foie. Pancreas. Abdomen - Gastroenterology. Liver. Pancreas. Abdomen - Foie. Voies biliaires. Circulation portale. Pancréas exocrine - Liver. Biliary tract. Portal circulation. Exocrine pancreas - Tumeurs - Tumors - Hemopathies - Hematologic and hematopoietic diseases - Leucémies. Lymphomes malins. Réticuloses malignes. Hématodermies. Splénomégalie myéloïde - Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis - Techniques d'exploration et de diagnostic (generalites) - Investigative techniques, diagnostic techniques (general aspects) - Anatomopathologie. Exploration cytologique. Biochimie. Spectrométries. Méthodes cliniques et paracliniques diverses - Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques - Cancer - Cáncer - Pathologie de l'appareil digestif - Digestive diseases - Aparato digestivo patología - Pathologie du pancréas - Pancreatic disease - Páncreas patología - Syndrome lymphoprolifératif - Lymphoproliferative syndrome - Linfoproliferativo síndrome - Tumeur maligne - Malignant tumor - Tumor maligno - Adénocarcinome du pancréas - Pancreas adenocarcinoma - Adenocarcinoma páncreas - Anatomopathologie - Anatomic pathology - Anatomía patológica - Cancer du pancréas - Pancreas cancer - Cáncer del páncreas - Hémopathie maligne - Malignant hemopathy - Hemopatía maligna - Leucémie - Leukemia - Leucemia - Lymphome - Lymphoma - Linfoma - Mime - Mimic - Mimo - Pancréas - Pancreas - Páncreas - Primaire - Primary - Primario - Hémopathie maligne lymphoïde - Lymphoid neoplasm - Hematologic malignancy - Pancreatic adenocarcinoma - Primary pancreatic lymphoma

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Use of WALLANT technique in hand surgery, safe and advantageous Personal experience
Mihaela Pertea;Vladimir Poroch;Oxana-Madalina Grosu;Alina Manole;Natalia Ve...
Academic Journal Academic Journal | Journal of Clinical and Investigative Surgery, Vol 3, Iss 1, Pp 26-31 (2018) Please log in to see more details
Objectives. To confirm the efficiency of using local anesthesia with lidocaine and epi... more
Use of WALLANT technique in hand surgery, safe and advantageous Personal experience
Journal of Clinical and Investigative Surgery, Vol 3, Iss 1, Pp 26-31 (2018)
Objectives. To confirm the efficiency of using local anesthesia with lidocaine and epinephrine in hand surgery. Materials and methods. 75 patients in whom we used local anesthesia with 1% lidocaine and epinephrine in solution 1: 100 000. We evaluated the amount of used anesthetic, the time to onset of anesthesia, intraoperative bleeding, the duration of intervention and hospitalization, immediate postoperative complications. Results. It has been no case of digital necrosis or other vascular complications and no intraoperative bleeding. The amount of the used anesthetic varied. In no case it was necessary to use of phentolamine as an antidote to the effects of adrenaline. Conclusions. Wide awake local anesthesia no tourniquet technique is safe, having many advantages: it is not necessary to use the tourniquet with or without intravenous sedation, the surgeon and patient comfort is maximum, there is no risk of digital necrosis, hospitalization time is short and the costs are minimal.

Subject terms:

hand surgery - wide awake - local anesthesia - Medicine

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Performance Evaluation of New Automated Hepatitis B Viral Markers in the Clinical Laboratory: Two Quantitative Hepatitis B Surface Antigen Assays and an HBV Core―Related Antigen Assay
PARK, Yongjung;DUCK JIN HONG;SHIN, Saeam;CHO, Yonggeun;KIM, Hyon-Suk
Academic Journal Academic Journal | American journal of clinical pathology. 137(5):770-777 Please log in to see more details
We evaluated quantitative hepatitis B surface antigen (qHBsAg) assays and a hepatitis ... more
Performance Evaluation of New Automated Hepatitis B Viral Markers in the Clinical Laboratory: Two Quantitative Hepatitis B Surface Antigen Assays and an HBV Core―Related Antigen Assay
American journal of clinical pathology. 137(5):770-777
We evaluated quantitative hepatitis B surface antigen (qHBsAg) assays and a hepatitis B virus (HBV) core―related antigen (HBcrAg) assay. A total of 529 serum samples from patients with hepatitis B were tested. HBsAg levels were determined by using the Elecsys (Roche Diagnostics, Indianapolis, IN) and Architect (Abbott Laboratories, Abbott Park, IL) qHBsAg assays. HBcrAg was measured by using Lumipulse HBcrAg assay (Fujirebio, Tokyo, Japan). Serum aminotransferases and HBV DNA were respectively quantified by using the Hitachi 7600 analyzer (Hitachi High-Technologies, Tokyo, Japan) and the Cobas AmpliPrep/Cobas TaqMan test (Roche). Precision of the qHBsAg and HBcrAg assays was assessed, and linearity of the qHBsAg assays was verified. All assays showed good precision performance with coefficients of variation between 4.5% and 5.3% except for some levels. Both qHBsAg assays showed linearity from 0.1 to 12,000.0 IU/mL and correlated well (r = 0.9934). HBsAg levels correlated with HBV DNA (r = 0.3373) and with HBcrAg (r = 0.5164), and HBcrAg also correlated with HBV DNA (r = 0.5198; P < .0001). This observation could provide impetus for further research to elucidate the clinical usefulness of the qHBsAg and HBcrAg assays.

Subject terms:

Medical oncology - Cancérologie - Medical laboratory techniques - Techniques de laboratoire médical - General medicine general surgery - Médecine et chirurgie générales - Sciences biologiques et medicales - Biological and medical sciences - Sciences medicales - Medical sciences - Pathologie infectieuse - Infectious diseases - Viroses - Viral diseases - Viroses humaines - Human viral diseases - Hépatites virales - Viral hepatitis - Techniques d'exploration et de diagnostic (generalites) - Investigative techniques, diagnostic techniques (general aspects) - Anatomopathologie. Exploration cytologique. Biochimie. Spectrométries. Méthodes cliniques et paracliniques diverses - Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques - Infection - Infección - Pathologie de l'appareil digestif - Digestive diseases - Aparato digestivo patología - Pathologie du foie - Hepatic disease - Hígado patología - Virose - Viral disease - Virosis - Analyse automatique - Automatic analysis - Análisis automático - Analyse quantitative - Quantitative analysis - Análisis cuantitativo - Anatomopathologie - Anatomic pathology - Anatomía patológica - Antigène HBc - Hepatitis B core antigen - Antígeno hepatitis BC - Antigène HBs - Hepatitis B surface antigen - Antígeno HBs - Dosage - Assay - Dosificación - Evaluation performance - Performance evaluation - Evaluación prestación - Hépatite virale B - Viral hepatitis B - Hepatitis vírica B - Indicateur biologique - Biological indicator - Indicador biológico - Laboratoire - Laboratory - Laboratorio - Marqueur biologique - Biological marker - Marcador biológico - Virus - Architect HBsAg QT - Elecsys HBsAg II quant - HBcrAg - HBsAg - Hepatitis B core-related antigen - Lumipulse HBcrAg - Quantitative HBsAg assay

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Laboratory Persistence and Clinical Progression of Small Monoclonal Abnormalities
MURRAY, David L;SENINGEN, Justin L;DISPENZIERI, Angela;SNYDER, Melissa R;KY...
Academic Journal Academic Journal | American journal of clinical pathology. 138(4):609-613 Please log in to see more details
Monoclonal gammopathy of undetermined significance (MGUS) that presents with no quanti... more
Laboratory Persistence and Clinical Progression of Small Monoclonal Abnormalities
American journal of clinical pathology. 138(4):609-613
Monoclonal gammopathy of undetermined significance (MGUS) that presents with no quantifiable Mspike on immunofixation electrophoresis (IFE) can be termed IFE MGUS. We retrospectively identified patients with IFE MGUS who were monitored with at least 1 subsequent assessment that included an IFE, and evaluated the persistence of the monoclonal protein and the progression of disease. Although the monoclonal proteins persisted in the majority of patients, 16% did not experience this persistence, and had no documented immunomodulatory therapy. After a median follow-up of 3.9 years, the disease clinically progressed in 14 patients (3.2%). Eight of these 14 patients with clinical progression had an immunoglobulin (Ig) A IFE Mprotein and 6 had an IgG Mprotein. This study demonstrates that in some patients with IFE MGUS, the Mproteins are transient and that IgA IFE MGUS is more likely to persist and progress to myeloma.

Subject terms:

Medical oncology - Cancérologie - Medical laboratory techniques - Techniques de laboratoire médical - General medicine general surgery - Médecine et chirurgie générales - Sciences biologiques et medicales - Biological and medical sciences - Sciences medicales - Medical sciences - Immunopathologie - Immunopathology - Immunodéficits. Immunoglobulinopathies - Immunodeficiencies. Immunoglobulinopathies - Immunoglobulinopathies - Techniques d'exploration et de diagnostic (generalites) - Investigative techniques, diagnostic techniques (general aspects) - Anatomopathologie. Exploration cytologique. Biochimie. Spectrométries. Méthodes cliniques et paracliniques diverses - Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques - Immunoglobulinopathie - Immunoglobulinopathy - Inmunoglobulinopatía - Immunopathologie - Immunopathology - Inmunopatología - Anatomopathologie - Anatomic pathology - Anatomía patológica - Anomalie - Anomaly - Anomalía - Electrophorèse - Electrophoresis - Electroforesis - Evolution - Evolución - Gammapathie monoclonale de signification indéterminée - Monoclonal gammopathy of undetermined significance - Gamapatía monoclonal de significancia indeterminada - Immunofixation - Inmunofijación - Immunoglobuline monoclonale - Monoclonal immunoglobulin - Inmunoglobulina monoclonal - Laboratoire - Laboratory - Laboratorio - Persistance - Persistence - Persistencia - Immunofixation electrophoresis - MGUS - Progression

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American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology Screening Guidelines for the Prevention and Early Detection of Cervical Cancer
SASLOW, Debbie;SOLOMON, Diane;WENTZENSEN, Nicolas;DOWNS, Levi S;SPITZER, Ma...
Academic Journal Academic Journal | American journal of clinical pathology. 137(4):516-542 Please log in to see more details
An update to the American Cancer Society (ACS) guideline regarding screening for the e... more
American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology Screening Guidelines for the Prevention and Early Detection of Cervical Cancer
American journal of clinical pathology. 137(4):516-542
An update to the American Cancer Society (ACS) guideline regarding screening for the early detection of cervical precancerous lesions and cancer is presented. The guidelines are based on a systematic evidence review, contributions from 6 working groups, and a recent symposium cosponsored by the ACS, the American Society for Colposcopy and Cervical Pathology, and the American Society for Clinical Pathology, which was attended by 25 organizations. The new screening recommendations address age-appropriate screening strategies, including the use of cytology and high-risk human papillomavirus (HPV) testing, follow-up (eg, the management of screen positives and screening intervals for screen negatives) of women after screening, the age at which to exit screening, future considerations regarding HPV testing alone as a primary screening approach, and screening strategies for women vaccinated against HPV16 and HPV18 infections.

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Amérique du Nord - North America - America del norte - Amérique - America - Etats-Unis - United States - Estados Unidos - Medical oncology - Cancérologie - Medical laboratory techniques - Techniques de laboratoire médical - General medicine general surgery - Médecine et chirurgie générales - Sciences biologiques et medicales - Biological and medical sciences - Sciences medicales - Medical sciences - Gynecologie. Andrologie. Obstetrique - Gynecology. Andrology. Obstetrics - Pathologie de l'appareil génital femelle - Female genital diseases - Tumeurs - Tumors - Techniques d'exploration et de diagnostic (generalites) - Investigative techniques, diagnostic techniques (general aspects) - Anatomopathologie. Exploration cytologique. Biochimie. Spectrométries. Méthodes cliniques et paracliniques diverses - Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques - Cancer - Cáncer - Pathologie de l'appareil génital femelle - Female genital diseases - Aparato genital hembra patología - Pathologie du col de l'utérus - Uterine cervix diseases - Cuello útero patología - Américain - American - Americano - Anatomopathologie - Anatomic pathology - Anatomía patológica - Cancer du col de l'utérus - Cervical cancer - Cáncer de cuello del útero - Colposcopie - Colposcopy - Colposcopía - Diagnostic - Diagnosis - Diagnóstico - Dépistage - Medical screening - Descubrimiento - Détection - Detection - Detección - Précoce - Early - Precoz - Prévention - Prevention - Prevención - Recommandation - Recommendation - Recomendación - Tumeur maligne - Malignant tumor - Tumor maligno

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Underrecognition of Pathologist Contributions to Articles Published in a Major Multidisciplinary Medical Journal
FRANKO, Angela D;WRIGHT, James R;TROTTER, Martin J
Academic Journal Academic Journal | American journal of clinical pathology. 138(4):495-497 Please log in to see more details
The Canadian Medical Association Journal (CMAJ) is a high-impact multidisciplinary med... more
Underrecognition of Pathologist Contributions to Articles Published in a Major Multidisciplinary Medical Journal
American journal of clinical pathology. 138(4):495-497
The Canadian Medical Association Journal (CMAJ) is a high-impact multidisciplinary medical journal. We have observed instances in which a pathology diagnosis, documented with gross or microscopic images, forms an integral part of a CMAJ article, but a pathologist is neither an author nor acknowledged as a contributor. To examine the hypothesis that pathologist contributions are underrecognized and/ or underdocumented, we reviewed all CMAJ articles over a 6-year period (September 2003-2009), and correlated the use of pathology images with pathologist authorship or contribution. For each article containing pathology images, department affiliations of authors were determined, and acknowledgments were assessed. Although only 1.7% of articles contained pathology images, 47% (26/55) of these articles did not include a pathologist as either an author or a contributor. We conclude that important intellectual contributions of pathologists are underrecognized and suggest that the scientific credibility of pathology data is in doubt when pathologists do not take on full responsibility of authorship or are not acknowledged as contributors.

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Medical oncology - Cancérologie - Medical laboratory techniques - Techniques de laboratoire médical - General medicine general surgery - Médecine et chirurgie générales - Sciences biologiques et medicales - Biological and medical sciences - Sciences medicales - Medical sciences - Techniques d'exploration et de diagnostic (generalites) - Investigative techniques, diagnostic techniques (general aspects) - Anatomopathologie. Exploration cytologique. Biochimie. Spectrométries. Méthodes cliniques et paracliniques diverses - Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques - Anatomopathologie - Anatomic pathology - Anatomía patológica - Article - Artículo - Critère - Criterion - Criterio - Exigence - Requirement - Exigencia - Multidisciplinaire - Multidisciplinary - Multidisciplinar - Médecine - Medicine - Medicina - Radiologue - Radiologist - Radiólogo - Authorship criteria - Intellectual content - Multidisciplinary medical journal - Pathologist - Uniform requirements for manuscripts (URM)

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A Population-Based Clinical Trial Comparing Endocervical High-Risk HPV Testing Using Hybrid Capture 2 and Cervista From the SHENCCAST II Study
BELINSON, Jerome L;RUIFANGWU;YING LIU;PRETORIUS, Robert G;BELINSON, Suzanne...
Academic Journal Academic Journal | American journal of clinical pathology. 135(5):790-795 Please log in to see more details
Our objective was to directly compare the accuracy of the high-risk human papillomavir... more
A Population-Based Clinical Trial Comparing Endocervical High-Risk HPV Testing Using Hybrid Capture 2 and Cervista From the SHENCCAST II Study
American journal of clinical pathology. 135(5):790-795
Our objective was to directly compare the accuracy of the high-risk human papillomavirus (HPV) assays, Hybrid Capture 2 (hc2; Qiagen, Gaithersburg, MD) and Cervista (Hologic, Bedford, MA), in diagnosing cervical intraepithelial neoplasia (CIN) 3 or worse (cancer). A population-based, cross-sectional study (The Shenzhen Cervical Cancer Screening Trial II) was conducted in Guangdong Province in China. Three high-risk HPV assays, self and direct cervical sampling and cytology, were studied. Abnormal results on any of 6 study tests (33%) resulted in referral to colposcopy. At colposcopy, every patient had at least 5 cervical biopsy specimens obtained For 8, 556 women between the ages of 25 and 59 years (mean, 38.9 years), the rate for CIN 3 or worse was 1.6% (141/8,556). The sensitivity (confidence interval) values for CIN 3 or worse were 97.9% (94.0%-99.6%) and 95.1% (90.0%-98.0%) for hc2 and Cervista, respectively (P > 05). The specificity (confidence interval) values were 87.8% (87.1%-88.5%) and 90.3% (89.6%-90.9%), respectively (P < .05). Differences in accuracy in diagnosing CIN 3 or worse with the hc2 and Cervista tests are minor and result from the decisions made in selecting the cut points.

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Medical oncology - Cancérologie - Medical laboratory techniques - Techniques de laboratoire médical - General medicine general surgery - Médecine et chirurgie générales - Sciences biologiques et medicales - Biological and medical sciences - Sciences medicales - Medical sciences - Pathologie infectieuse - Infectious diseases - Viroses - Viral diseases - Gynecologie. Andrologie. Obstetrique - Gynecology. Andrology. Obstetrics - Pathologie de l'appareil génital femelle - Female genital diseases - Tumeurs - Tumors - Techniques d'exploration et de diagnostic (generalites) - Investigative techniques, diagnostic techniques (general aspects) - Anatomopathologie. Exploration cytologique. Biochimie. Spectrométries. Méthodes cliniques et paracliniques diverses - Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques - Cancer - Cáncer - Infection - Infección - Papillomavirus - Papovaviridae - Pathologie de l'appareil génital femelle - Female genital diseases - Aparato genital hembra patología - Pathologie du col de l'utérus - Uterine cervix diseases - Cuello útero patología - Tumeur maligne - Malignant tumor - Tumor maligno - Virus - Anatomopathologie - Anatomic pathology - Anatomía patológica - Cancer du col de l'utérus - Cervical cancer - Cáncer de cuello del útero - Capture - Captura - Col utérus - Uterine cervix - Cuello útero - Dépistage - Medical screening - Descubrimiento - Essai clinique - Clinical trial - Ensayo clínico - Etude comparative - Comparative study - Estudio comparativo - Homme - Human - Hombre - Hybride - Hybrid - Híbrido - Papillomavirus humain - Human papillomavirus - Population - Población - Risque élevé - High risk - Riesgo alto - Virose - Viral disease - Virosis - Cervical cancer screening - Cervista - HPV - Hybrid Capture 2

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