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Medičnì Perspektivi
Academic Journal Academic Journal | 09/02/2015 Please log in to see more details
Medičnì Perspektivi
09/02/2015

Subject terms:

social medicine - theoretical medicine - clinical medicine - preventive medicine - Medicine (General)

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Medičnì Perspektivi
Medičnì Perspektivi
09/02/2015

Subject terms:

social medicine - theoretical medicine - clinical medicine - preventive medicine - Medicine (General) - R5-920

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The comparative analysis of antiparkinsonian activity of glycine combined with amantadine in conditions of changing neurosynaptic transmission
Mamchur V.I.;Kryvoruchko T.N.;Makarenko O.V.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 3, Pp 11-16 (2017) Please log in to see more details
Parkinson's disease is traditionally viewed as a disease which affects the human motor... more
The comparative analysis of antiparkinsonian activity of glycine combined with amantadine in conditions of changing neurosynaptic transmission
Medičnì Perspektivi, Vol 22, Iss 3, Pp 11-16 (2017)
Parkinson's disease is traditionally viewed as a disease which affects the human motor sphere. Besides motor manifestations in the clinical picture of the disease, non-motor manifestations with dementia as the most common are present. The purpose of the work – experimental evaluation of the possible antiparkinsonian action of glycine in terms of experimental models of Parkinson's disease equivalents (akinetic-rigid and tremor forms) on the background of antiparkinsonian correction by amantadine. Methods: catalepsy model (inhibition of dopaminergic transmission, equivalents of hypokinesia and rigidity states) and model of arekolyn tremor (activation of cholinergic transmission that corresponds to parkinsonian tremor) on the background of amantadine administration (50 mg/kg), glycine (100 mg/kg and 200 mg/kg) and their combined introduction. The research results show a positive dynamic in combined using of amantadine with glycine at a dose of 100 mg/kg and 200 mg/kg, which was is determined by the low percentage of animals with symptoms of catalepsy (50-70%) with evaluation criteria of 0.5-1.8 points with maximum possible 6 points. Similar results were obtained in terms of activation of the cholinergic system (arekolyn tremor). Glycine at a dose of 100 mg/kg and 200 mg/kg facilitated to optimization of antitremor action of amantadine, that is registered in increased latent period of tremor, reduction of its duration and intensity attenuation almost by 2,1 times in comparison with indicators of the control group. Thus, studied combinations of amantadine with glycine at a dose of 100 mg/kg and 200 mg/kg are promising in studying of their influence on dementia in Parkinson's syndrome, and this study will be continued.

Subject terms:

Parkinson's syndrome - catalepsy - tremor - amantadine - glycine - Medicine (General)

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Clinical, general, hemocoagulation and pathologicanatomical features of patients with moderate and severe community acquired pneumonia by the data of retrospective analysis
Pertseva T.A.;Kireyeva T.V.;Bielosludtseva K.O.;Kryhtіna M.A.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 3, Pp 17-24 (2017) Please log in to see more details
According to literature data, patients with community acquired pneumonia (CAP) fall in... more
Clinical, general, hemocoagulation and pathologicanatomical features of patients with moderate and severe community acquired pneumonia by the data of retrospective analysis
Medičnì Perspektivi, Vol 22, Iss 3, Pp 17-24 (2017)
According to literature data, patients with community acquired pneumonia (CAP) fall into several groups of unfavorable prognostic factors. Development of thrombotic complications is one of causes of mortality of hospitalized patients. In this case systemic inflammation, which is always present in moderate and severe CAP, is the starting mechanism of formation of disorders in the hemostasis system. The aim of our work was to determine anamnestic, clinical, laboratory and pathologic anatomical features in patients with CAP, taking into account markers of systemic inflammation and coagulogram indices, as well as predicting the occurrence of complications. In the course of the work, a retrospective analysis of 151 medical histories of hospitalized patients with CAP was made. We analyzed anthropometric indicators, complaints at the time of hospitalization, results of physical examination, results of the chest X-ray, clinical and laboratory indicators, microbiological sputum analysis and to assess the possibility of thrombotic complications a RAM scale was used. It was found that late asking for medical help, the presence of mixed infection, underestimation of the severity of condition and severe systemic inflammation increase the risk of lethal outcome in patients with CAP. Considering a high risk of thrombosis in patients with CAP, it is necessary to assess the risk of thrombotic complications with the help of special scales, as well as timely detection and correction of disorders from the hemostasis system.

Subject terms:

community acquired pneumonia - complications - thrombosis - Medicine (General)

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Minimally-invasive and endovideosurgical technologies in diagnosis and treatment of choledocholithiasis
Kutovoy A.;Rodinskaya G.;Balyk D.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 3, Pp 41-45 (2017) Please log in to see more details
The paper presents the results of the use of minimally-invasive methods in the diagnos... more
Minimally-invasive and endovideosurgical technologies in diagnosis and treatment of choledocholithiasis
Medičnì Perspektivi, Vol 22, Iss 3, Pp 41-45 (2017)
The paper presents the results of the use of minimally-invasive methods in the diagnosis and treatment of choledocholithiasis. The results of treatment of 595 patients aged from 24 to 92 years with the diagnosis of choledocholithiasis were evaluated. In 552 (93,0%) patients, clinical ma­nifestations of mechanical icterus were noted. In 508 (85,3%) patients, choledocholithiasis was combined with the presence of gallstones, in 15 (2,5%) cases – with calculous cholecystitis, in 69 (11,6%) cases - choledocholithiasis was residual. For the diagnosis of choledocholithiasis, ultrasound of the abdominal cavity, computed tomography, endoscopic retrograde cholangiopancreatogy, percutaneous fistulocholangiography, intraoperative cholangiography or cholangiography were used. Surgical treatment included both mini-invasive interventions and traditional operations. 227 (38,1%) patients underwent endoscopic papillosphincterotomy, which was effective in a size of concrement up to 7 mm in 83,7%. The percutaneous drainage of the bille ducts was performed in 88 (14,7%) patients, the efficacy was achieved in 82,9%. 313 (52,6%) patients subsequently underwent the second stage of surgical treatment of choledocholithiasis by laparoscopy – 263 (84,0%) and laparotomy – 50 (16,0%) with cholecystectomy with choledocholithoextraction and subsequent external or internal drainage of choledochus. Comparison of different methods of investigation showed that none of the diagnostic techniques had 100% of accuracy and informative value. The efficacy of transpapillary manipulation directly depended on the size of the stones.

Subject terms:

сholedocholithiasis - diagnosis - surgical treatment - Medicine (General)

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Cognitive functions in the acute period of polytrauma and correction of their disorders with thiocetam
Krishtafor A.A.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 3, Pp 60-68 (2017) Please log in to see more details
Aim of the work – to evaluate the effectiveness of thiocetam as a medicine that preven... more
Cognitive functions in the acute period of polytrauma and correction of their disorders with thiocetam
Medičnì Perspektivi, Vol 22, Iss 3, Pp 60-68 (2017)
Aim of the work – to evaluate the effectiveness of thiocetam as a medicine that prevents cognitive impairments in patients with polytrauma, as well as to compare the scales of cognitive function assessment - MoCA and MMSE. We examined 50 victims with polytrauma without severe intracranial lesions, randomly divided into a control group (26 patients) and a main (24 patients) group. Patients of the control group received conventional intensive therapy for traumatic illness, patients of the main group in addition to this therapy received thiocetam. The somatic status was assessed according to the generally accepted clinical and laboratory indicators. The level of cognitive functions before the injury was assessed by the CFQ questionnaire for 2-3 days after the injury; The MoCA and MMSE scales were used on the 2nd day, when patients were transferred from the intensive care unit and before the discharge. The severity of injury was assessed by the ISS scale. The severity of the response to traumatic stress was assessed by the IES-R scale. In both groups, the baseline level of cognitive function was within the age range. On the second day after the trauma, significant inhibition of cognitive functions in both groups was noted, but in the main group this decrease was un­reliably less. At subsequent stages a gradual increase in both groups was noted, however, in the main group recovery of cognitive functions occurred more rapidly. After 3 months, decrease in cognitive functions preserved at a level when patients were discharged from the hospital. In the main group there were significantly fewer pa­tients whose posttraumatic stress after 3 months increased from minimal to low. When using the MoCA scale, there was a more pronounced decrease in cognitive functions than with the MMSE scale, but it in the less degree consider pecu­liarities of thinking. Thiocetam prevents the decrease of cognitive functions in patients with polytrauma and, due to that, also reduces the severity of posttraumatic stress reaction. For practical using in intensive care units it is preferable to use the MMSE scale.

Subject terms:

cognitive disorders - polytrauma - posttraumatic stress disorder - thiocetam - Medicine (General)

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Investigation of effectiveness of surgical treatment of chronic dacryocystitis - endonasal dacryocystorhinostomy
Borodulya V.L.;Grechka E.M.;Stepakhina M.E.;Derbina E.A.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 3, Pp 69-72 (2017) Please log in to see more details
Prolonged and conti­nuous lacrimation (symptom of epiphora) causes discomfort, inclina... more
Investigation of effectiveness of surgical treatment of chronic dacryocystitis - endonasal dacryocystorhinostomy
Medičnì Perspektivi, Vol 22, Iss 3, Pp 69-72 (2017)
Prolonged and conti­nuous lacrimation (symptom of epiphora) causes discomfort, inclination to conjunctiva infect, reduces visual acuity and ultimately the quality of life of the patient. Despite the fact that there is a large number of various surgical interventions to restore tearing in patients with chronic dacryocystitis, the problem of lacrimation remains relevant. We have studied the operation of endonasal dacryocystorhinostomy and its long-term consequences. Surgical intervention in endonasal dacryocystorhinostomy is aimed at eliminating lacrimation by eliminating stenosis and forming a new combination of the cavity of the laryngeal canal with the nasal cavity, as well as the sanation of purulent foci of infection in the throat. There were 8 surgical interventions. Period of observation of patients in the postoperative period by ophthalmologist and ENT-doctor is from 1.5 to 2 years. The evaluation of the result was carried out in 6 months or more after the operation. A complete recovery with the recovery of the tear excretion in the nasal cavity has been achieved in all patients. The formed rhinostoma was wide, well functioning. Thus, endonasal dacryocystorhinostomy is a highly effective and should be a method of choice for inflammation of the lacrimal sac at any stage of development.

Subject terms:

Endonasal dacryocystorhinostomy - chronic dacryocystitis - Medicine (General)

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Assessment of functional tests on determining resistance of respiratory tract in patients with bronchial asthma, COPD and their combination
Nazarenko K.V.;Opimakh S.G.;Polianskaja M.O.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 3, Pp 73-81 (2017) Please log in to see more details
The mechanical properties of the respiratory tract (including airway resistance) is an... more
Assessment of functional tests on determining resistance of respiratory tract in patients with bronchial asthma, COPD and their combination
Medičnì Perspektivi, Vol 22, Iss 3, Pp 73-81 (2017)
The mechanical properties of the respiratory tract (including airway resistance) is an important indicator of pulmonary function, and definition of resistance is used to diagnose and monitor obstructive lung diseases. This study was performed in order to evaluate and compare functional results of tests to determine the resistance of the airways in patients with asthma, chronic obstructive pulmonary disease and their combination. The study involved 191 patients: with asthma (n=34), with COPD (n=17) and their combination (n=140). Patients underwent bodyplethysmography and impulse oscillometry. A statistically significant correlation of medium strength between parameters of the total resistance, determined with the help of bodyplethysmography and impulse oscillometry, r=0.57, p<0.001. According to ROC-analysis, the best point of distribution of normal and pathological parameters of impulse oscillometry (R5Hz) as a diagnosis of increased respiratory resistance is 130% and higher from the proper values. The area under the ROC curve is 0.807. When interpreting the results of impulse oscillometry in patients with asthma, COPD and their combination, R5Hz level equal to or exceeding 130% of the proper values is proposed to be regarded as a sign of an increased respiratory resistance with sensitivity of technique – 64.0%, specificity – 87.5% and prognostic value of the positive result - 98.2%.

Subject terms:

asthma - COPD - asthma-COPD overlap - airway resistance - Medicine (General)

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HLA DRB1 polymorphism and risk of HIV/tuberculosis co-infection
Shostakovych-Koretskaya L.R.;Volikova O.O.;Lytvyn K.Y.;Gubar I.O.;Kushnerov...
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 3, Pp 81-88 (2017) Please log in to see more details
In the research data on the study of interconnection between polymorphism of HLA DRB1 ... more
HLA DRB1 polymorphism and risk of HIV/tuberculosis co-infection
Medičnì Perspektivi, Vol 22, Iss 3, Pp 81-88 (2017)
In the research data on the study of interconnection between polymorphism of HLA DRB1 genes and the risk of HIV infection and co-infection and HIV/tuberculosis are presented. The cohort of observation was HIV-infected individuals with different clinical stages aged from 24 to 58 years, average age being 38 years. 90 patients (89.2%) received HAART. There were 32 (31.4%) HIV-infected patients with manifestations of tuberculosis, 70 (68.6%) HIV patients without manifestations of tu­ber­culosis. Among the cohort of HIV-infected patients with manifestations of tuberculosis, pulmonary forms of tuberculosis was in 32 (100%), of which extrapulmonary forms of tuberculosis were in 12 (37.5%) patients. The majority of cases of tuberculosis occurred in HIV-infected patients in the IV clinical stage. Among HIV-infected patients, the following alleles of the HLA gene DRB1 *01 (10%) *04 (10%) *07 (13%), *11 (15%), *13 (13%), *15 (10%) occurred more often, HLA DRB1 *03 *08 *09 *10, *12, *14, *16, * 17, *18 were rarely found (1-7%). Similar distributions of DRB1 genes were noted among residents of the region with the dominance of HLA DRB1 *01 *04 *07 *11 *13 and *15. With the presence of alleles of the locus DRB1 *13, DRB1 *03 and DRB1 *08, the greatest probability of co-infection of tuberculosis was observed in HIV-infected patients. The risk of tuberculosis is by 2 times higher with a significant difference in HIV-infected patients with DRB1 *13 locus alleles, DRB1 *03 – by 4.4 times and DRB1 *08 – by 5.4 times. Significant chances of tuberculosis occurrence are higher – by 2.6 times in HIV-infected patients with DRB1 *13 locus alleles, DRB1 *03 – by 5.1 times and DRB1 *08 – by 6.4 times. Thus, the variability of the HLA DRB1 locus alleles may play a predisposing or protective role in the occurrence of tuberculosis in HIV-infected patients.

Subject terms:

HLA DRB1 gene polymorphism - HIV-infected patients - co-infection HIV/tuberculosis - Medicine (General)

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Risk factors and features of recurrent bacterial complications of upper respiratory tract viral infections in children
Karpenko A.V.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 3, Pp 88-93 (2017) Please log in to see more details
The aim of the study was to determine risk factors for recurrent bacterial complicatio... more
Risk factors and features of recurrent bacterial complications of upper respiratory tract viral infections in children
Medičnì Perspektivi, Vol 22, Iss 3, Pp 88-93 (2017)
The aim of the study was to determine risk factors for recurrent bacterial complications of the upper respiratory tract viral infection (URTI) in children, as well as the clinical and immunological features of the course of such complications. We enrolled 214 children aged 3-18 years with URTIs complicated with acute otitis media or acute bacterial rhinosinusitis. Frequency of bacterial complications of URI in 128 children was low (group I) and in 86 children it met the criteria of recurrent course (group II). In addition to the standard examination, lysozyme levels in the oropharyngeal secretion were determined three times during the disease. It was found that children of group II were characterized by an early debut of respiratory morbidity (at the age of 6.00 (4.00, 12.00) months against 13.00 (4.50, 16.00) months in children of group I (p<0,0001), as well as a longer duration of catarrhal and intoxication syndromes in similar forms of the disease. The most significant risk factors for the formation of the recurring complication pattern were maternal smoking (OR=2.73, 95% CI [1.34, 5.48]), along with gastroenterological pathology and frequent URTI in the mother and a shortened period of breastfeeding. In children with recurrent bacterial complications of URTI, there was an impaired local resistance of the upper respiratory tract mucous membranes (as a decrease in the concentrations of lysozyme) in all periods of the disease, which persisted after recovery.

Subject terms:

acute otitis media - acute rhinosinusitis - URTI - lysozyme - children - Medicine (General)

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Immunohistochemical expression of intermediate filaments in diagnostics of diffuse gliomas
Shynkarenko T.V.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 3, Pp 93-98 (2017) Please log in to see more details
Intermediate filament proteins play an important role in maintaining a stable shape, a... more
Immunohistochemical expression of intermediate filaments in diagnostics of diffuse gliomas
Medičnì Perspektivi, Vol 22, Iss 3, Pp 93-98 (2017)
Intermediate filament proteins play an important role in maintaining a stable shape, as well as the possible movement of cells, including neoplastic cells. However there, are few works dedicated to the investigation of these proteins expression in diffuse gliomas and they are quite contradictory. The authors studied the expression of intermediate filaments (glial fibrillar acid protein GFAP, vimentin) in diffuse gliomas of the brain. 52 postoperative samples with the diagnosis of astrocytic and oligodendroglial brain tumors were examined. Primary antibodies against GFAP, vimentin, Ki-67 were used. The proliferative index and the expression area were calculated using the tools ImageJ 1.47v. The statistical Fisher test was included. Most samples with moderate expression of GFAP (62.5%) are rated to oligodendroglial tumors. Part of oligodendroglial tumors (58.3%) showed no expression of vimentin by tumor cells, this was not observed in astrocytomas. Meanwhile, a high level of expression of intermediate filament proteins - GFAP (100%) and vimentin (87%) is characteristic for diffuse gliomas. The expression level of GFAP and vimentin is higher in astrocytic tumors than in oligodendroglial (p<0.05). Levels of GFAP and vimentin expression are differential feature of astrocytic and oligodendroglial tumors.

Subject terms:

brain tumor - mmunohistochemistry - diagnostics - vimentin - GFAP - Medicine (General)

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Characteristics of the microvascular bed of rats’ testis exposed to electromagnetic field and using immunomodulator
Sharapova Ye.N.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 3, Pp 113-116 (2017) Please log in to see more details
As a result at studies performed there were defined morphofunctional changes in the st... more
Characteristics of the microvascular bed of rats’ testis exposed to electromagnetic field and using immunomodulator
Medičnì Perspektivi, Vol 22, Iss 3, Pp 113-116 (2017)
As a result at studies performed there were defined morphofunctional changes in the structyre of microvascular bed of rats’ testes, exposed to electromagnetic field during 30-45 days, later they were receiving 7% Echinacea purple tincture. It was established that in these experimental terms the structure of testicular vessels was significantly different by morphologic structure. On the day 30 in the structure of micro­hemocirculatory bed of testes there was defined an insignificant blood-filling of the venous bed. There were neither spasms of arteries, which formed cellular structure in the testicular tissue, no edematous signs. On the day 45 of the experiment in the testes of the irradiated rats there was noted more expressed bifurcation of arterial vessels and decrease of blood-filling of veins without expressed venous stasis. With the increase of irradiation term by electromagnetic field up to 45 days and usage of Echinacea purpura tincture there were noted reverse phenomena in hemacicrulatory bed of rats’ testes in the form of widening of arterial chain of vessels and narrowing of venons chain of the vessels; this led to increase of index of medium diameter of seminal tubules and subsequently, to the increase of the total area of spermatogenous tissue of rats.

Subject terms:

electromagnetic field - Echinacea purple tincture - testicle - seminal tubule - Medicine (General)

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He lived for the sake of people. To the 180th anniversary of the Ekaterinoslav zemstvo doctor V.T. Skrylnikov (1837-1898) (part 2)
Pisarenko Yu.G.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 2, Pp 141-151 (2017) Please log in to see more details
The second part of the essay about zemstvo doctor, V.T. Skrylnikov elucidates his frui... more
He lived for the sake of people. To the 180th anniversary of the Ekaterinoslav zemstvo doctor V.T. Skrylnikov (1837-1898) (part 2)
Medičnì Perspektivi, Vol 22, Iss 2, Pp 141-151 (2017)
The second part of the essay about zemstvo doctor, V.T. Skrylnikov elucidates his fruitful activity in the field of balneology: study and popularization of therapeutic properties of the so-called "Timofeev clay", publication of his "Seasonal Bulletin of Slaviansk mineral water ". We describe recent years of the doctor’s life, complicated with the disease and severe family affairs. The grateful memories of his fellow doctors about him are listed.

Subject terms:

V.T. Skrylnikov - balneology - Timofeyev clay - Seasonal Bulletin of Slaviansk mineral water - Medicine (General)

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The role of polymorphism of genes of the I and II phase of xenobiotics biotransformation in the development of recurrent and chronic bronchitis in adolescent-smokers
Il'chenko S.I.;Fialkovskaia A.А.;Kramarenko N.N.;Makukh G.V.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 2, Pp 85-90 (2017) Please log in to see more details
The purpose of research – to study the role of allelic polymorphism of genes of the I ... more
The role of polymorphism of genes of the I and II phase of xenobiotics biotransformation in the development of recurrent and chronic bronchitis in adolescent-smokers
Medičnì Perspektivi, Vol 22, Iss 2, Pp 85-90 (2017)
The purpose of research – to study the role of allelic polymorphism of genes of the I and II phases of xenobiotics biotransformation in the development of reccurent and chronic diseases of the respiratory system in adolescent-smokers. There was carried out molecular-genetic study of the polymorphic locus Т3801С of gene CYP1A1 and polymorphic locus A313G of gene GSTP1 in adolescent-smokers with recurrent and chronic bronchitis. It is established that TТ genotype of the polymorphic locus Т3801С of gene CYP1A is a marker of resistance to the development of this pathology in adolescent-smokers. The presence of CC genotype of the polymorphic locus Т3801С of gene CYP1A1 and GG genotype of polymorphic locus of A313G GSTP1 gene may be considered as a possible risk factor for the development of chronic inflammatory process in bronchopulmonary system. Thus, the introduction of molecular-genetic methods of research opens up new possibilities in diagnosis of recurrent and chronic diseases of the respiratory system. Based on the analysis of genetic factors in children and adolescents, it will be possible to predict the risk of COPD developing in the future; this will allow doctors to carry out the necessary preventive activities among risk groups.

Subject terms:

recurrent and chronic bronchitis - adolescent-smokers - gene CYP1A1 - gene GSTP1 - Medicine (General)

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Frequency of risk factors of cardiovascular diseases and renal functional state in patients with chronic heart failure with atrial fibrillation
Kuryata O.V.;Muhammad Muhammad;Mytrokhina O.S.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 2, Pp 36-43 (2017) Please log in to see more details
There are presented and analyzed the most common and important risk factors (RF) in pa... more
Frequency of risk factors of cardiovascular diseases and renal functional state in patients with chronic heart failure with atrial fibrillation
Medičnì Perspektivi, Vol 22, Iss 2, Pp 36-43 (2017)
There are presented and analyzed the most common and important risk factors (RF) in patients with chronic heart failure and atrial fibrillation (AF). The data indicate the need for more careful attention to this group of patients and the need in early diagnosis of AF RF and their active modification, which is very important for the development of effective measures both for the primary prevention of AF and prevention of progression of this disease.

Subject terms:

chronic heart failure - atrial fibrillation - risk factors - Medicine (General)

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Improvement of the system of supply of the Ukrainian Armed Forces with hemotransfusion agents
Zamkovyi A.D.;Tymchenko A.S.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 2, Pp 44-51 (2017) Please log in to see more details
The main research results substantiating the system of transfusion supply of military ... more
Improvement of the system of supply of the Ukrainian Armed Forces with hemotransfusion agents
Medičnì Perspektivi, Vol 22, Iss 2, Pp 44-51 (2017)
The main research results substantiating the system of transfusion supply of military medical facilities of the Armed Forces of Ukraine during peacetime and in the special period are presented. It was proved that the aim of development of blood bank is to create the system of provision with blood, its components and protein preparations of blood plasma of hospitals both in terms of daily activity and at the time of their usage.

Subject terms:

blood - blood component - settlement of accounts of blood component supplement of military medical facilities - Medicine (General)

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The impact of obesity on the structure of osteoarthrosis of large joints of the lower lim
Loskutov A.E.;Kuryata A.V.;Cherkasova A.V.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 2, Pp 52-59 (2017) Please log in to see more details
The prevalence of osteoarthrosis (OA) among adults over 40 years is taking one of the ... more
The impact of obesity on the structure of osteoarthrosis of large joints of the lower lim
Medičnì Perspektivi, Vol 22, Iss 2, Pp 52-59 (2017)
The prevalence of osteoarthrosis (OA) among adults over 40 years is taking one of the leading places in the common structure of joint pathology. Obesity – is of the comorbidities associated with OA, one of the risk factors of development and progression of OA. The aim of this study was to evaluate the influence of obesity on the structure of knee and hip OA on the stage of total joint replacement, depending on the patient`s gender, age and degree of obesity. The study involved 170 inpatient case histories of patients with OA undergoing treatment in the department of large joints replacement (64 men and 106 women): 95 patients with OA of hip joint and 75 – with OA of knee joint, among whom there were 110 patients with obesity and 60 – without it. The middle age of the patients was by 63,8±7,69 years. High prevalence of obesity among patients with OA of knee and hip joints was found, with significant higher number of obese patients with OA of knee joint and among female patients. It has been demonstrated a significant increase in the frequency of total knee joint replacement associated with the increase of body mass index among patients with OA of knee joint. The presence of obesity was associated with earlier terms of the total joint replacement performing, especially among male patients.

Subject terms:

obesity - osteoarthrosis of knee and hip joints - total joints replacement - Medicine (General)

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Mechanism of formation of oxalate concrements in the presence of ureaseproducing pathogens in urine (conception)
Vozianov S.A.;Koval D.V.;Rudenko A.V.;Zheltovska N.I.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 2, Pp 60-66 (2017) Please log in to see more details
The aim of the study was to as¬certain the role of U.urealyticum in formation of phosp... more
Mechanism of formation of oxalate concrements in the presence of ureaseproducing pathogens in urine (conception)
Medičnì Perspektivi, Vol 22, Iss 2, Pp 60-66 (2017)
The aim of the study was to as¬certain the role of U.urealyticum in formation of phosphates and oxalates in kidneys and factors promoting this pro¬cess. The work represents the author’s conception of this process. There were fully examined 79 patients with nephro¬lithiasis with the aim to determine the species difference of pathogenic agents of the accompanying inflammatory process and there was compared the chemical structure of the removed concrements. There was stated the role of the urease-producing bacteria (P.mirabilis and U.urealyticum) in the process of phosphate and oxalate lithogenesis and the accompanying factors, which initiate these reactions (urinary pH, endogenic urease, index of oxalic acid concentration). The work presents the comparative analysis of lithogenesis in the presence of accompanying bacteria of different taxonomic position. The authors’ conception of the role of U.urealyticum and P.mirabilis in lithogenesis has been elaborated.

Subject terms:

nephrolithiasis - urease-producing microorganisms - mineral composition of concrements - mechanism of lithogenesis - Medicine (General)

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Staged isolation of abdominal cavity in generalized peritonitis
Kutovoi А.;Kosulnikov S.;Zavizion E.;Stepanskyi D.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 2, Pp 66-71 (2017) Please log in to see more details
In the work we present comparative results of treatment of patients with generalized s... more
Staged isolation of abdominal cavity in generalized peritonitis
Medičnì Perspektivi, Vol 22, Iss 2, Pp 66-71 (2017)
In the work we present comparative results of treatment of patients with generalized secondary and tertiary peritonitis depending on the way of surgery completion. Patients in group I (n=27) underwent only skin suturing after the surgery, in group II –laporostoma was formed with VAC in the abdominal cavity. We have evaluated the level of microbe contamination and condition after wound surgery, intensity of adhesion process in the abdominal cavity, multiple organ failure after surgery. The use of laporostoma combined with VAC at different stages of generalized peritonitis treatment helps to achieve illness rigress, less number of planned saniations of abdominal cavity. Even after the first use of VAC, quicker clearance of operation wound and appearance of new granulation tis¬sues occurred. In group II in secondary saniation the frequency of fixing of abdominal cavity is developing 31,9% higher (p<0,05) and in the third saniation the use of VAC therapy resulted in growing number of patients with frozen abdomen.

Subject terms:

generalized peritonitis - programmed relaparotomy - abdominal cavity sanitations - VAC - Medicine (General)

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Heart rate variability in patients with hypertension combined with osteoarthrosis under the impact of antihypertensive therapy
Khmel O.S.;Rodionova V.V.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 2, Pp 71-78 (2017) Please log in to see more details
Objective: to investigate the heart rate variability in patients with HT and OA under ... more
Heart rate variability in patients with hypertension combined with osteoarthrosis under the impact of antihypertensive therapy
Medičnì Perspektivi, Vol 22, Iss 2, Pp 71-78 (2017)
Objective: to investigate the heart rate variability in patients with HT and OA under the influence of antihypertensive therapy. Materials and Methods: The study involved 60 persons, main group – 25 patients with HT stage II, 2nd degree, combined with knee OA of the II stage according to the Kellgren-Lawrence. The group of comparison consisted of 20 patients with HT stage II, 2nd degree. The control group consisted of 15 almost healthy individuals. During the study patients received antihypertensive therapy: Amlodipine 5 mg and Lisinopril 5 mg 1 time per day per os. The survey was carried out before and after the treatment. Results: in hypertensive patients with OA the influence of the sympathetic system and LF / HF index were reduced (before treatment – 5,64 [4,87–7,56], after treatment – 3,95 [3,74–4,54]; p<0,05); this indicates to decrease of influence of the sympathetic system on the organism. Conclusions: The presence of OA in patients with HT provides additional negative effect on the heart rate variability, which may testify to increasing mortality risk in these patients. Antihypertensive therapy with Lisinopril, 5 mg and Amlodipine, 5 mg in patients with HT and OA leads to improvement of hypertension course due to influence on sympathic system.

Subject terms:

heart rate variability - hypertension - osteoarthrosis - Medicine (General)

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Study of progesterone-induced blocking factor in the treatment of women with threatening abortion, taking into account the polymorphism of the progesterone receptor gene
Kryvopustov O.S.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 2, Pp 91-95 (2017) Please log in to see more details
Actual medical and social problem of modern obstetrics is threatening abortion. In its... more
Study of progesterone-induced blocking factor in the treatment of women with threatening abortion, taking into account the polymorphism of the progesterone receptor gene
Medičnì Perspektivi, Vol 22, Iss 2, Pp 91-95 (2017)
Actual medical and social problem of modern obstetrics is threatening abortion. In its treatment, analogues of progesterone are used. Activation of progesterone receptors induces the production of anti-abortive protein-progesterone-induced blocking factor (PIBF). The dynamics of PIBF in 28 patients with the diagnosis of threatening abortion was analyzed. Women were treated by natural micronized progesterone depending on the features of the clinical course and single nucleotide polymorphism of the progesterone receptor gene rs590688. The quantitative content of PIBF in urine in pregnant women with threatening abortion was determined, namely, the increase in the content of this factor is associated with the prolongation of pregnancy. At the time of initiation of therapy, the concentration of PIBP was 28.8±1.5 (95% CI 26.7-29.2) ng/ml, and on the 7th day of therapy its concentration was 29.4±0.1 (95% CI 29.2-29.5) ng/ml. The increase in PIBF has reached a degree of statistical significance (T-W=15.0, p<0.001). In 27 (96.4%) patients who were pregnant, PIBP levels increased, 1 (3.6%) patient had spontaneous miscarriage on the 9th day of treatment. She had a decrease in concentration of PIBF in urine from 29.18 ng/ml at the time of admission to the hospital to 28.58 ng/ml on the 7th day of therapy. The study of progesterone-induced-blocking factor can be considered as an additional laboratory method of controlling progesterone therapy in women with threatening abortion in specialized research institutions.

Subject terms:

threatened abortion - progesterone receptor gene polymorphism - progesterone induced blocking factor - natural micronized progesterone therapy - Medicine (General)

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Features of treatment of various clinical variants of generalized catarrhal gingivitis
Gudaryan А.А.;Kuznyak N.B.;Shostenko A.A.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 2, Pp 95-103 (2017) Please log in to see more details
The article presents the results of a complex treatment of 82 patients with generalize... more
Features of treatment of various clinical variants of generalized catarrhal gingivitis
Medičnì Perspektivi, Vol 22, Iss 2, Pp 95-103 (2017)
The article presents the results of a complex treatment of 82 patients with generalized catarrhal gingivitis at the stage of chronic and exacerbated course through the use of scientifically based programs for the step-by-step application of occupational hygiene measures, antibacterial and immunocorrective therapy. The performed step-by-step treatment of generalized catarrhal gingivitis contributes to rapid elimination of possible causative agents of the disease, provides elimination of the deficiency of local humoral immunity, imbalance in the cytokine system, leads to the elimination of inflammatory phenomena in the gum in 93.3% of patients with chronic course and in 96.3% of patients with exacerbated manifestation of the disease.

Subject terms:

generalized periodontitis - catarrhal gingivitis - microbiocenosis - Medicine (General)

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Clinical and laboratory efficacy of systemic enzyme therapy in patients with chronic generalized periodontitis complicated by purulent foci in soft periodontal tissues
Gudaryan А.А.;Kuznyak N.B.;Dronik I.I.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 2, Pp 104-110 (2017) Please log in to see more details
The article presents the results of complex treatment of 98 patients with chronic gene... more
Clinical and laboratory efficacy of systemic enzyme therapy in patients with chronic generalized periodontitis complicated by purulent foci in soft periodontal tissues
Medičnì Perspektivi, Vol 22, Iss 2, Pp 104-110 (2017)
The article presents the results of complex treatment of 98 patients with chronic generalized periodontitis with purulent foci in periodontal tissues by using standard complex treatment in combination with systemic enzyme therapy, which in turn allows to increase the effectiveness of the therapeutic measures and to eliminate etiological and pathogenetic links and regress of clinical symptoms of the disease. Under its influence, clinical and laboratory rehabilitation comes faster by 5.4 ± 0.2 days, and remission throughout the year takes place in 91.7% of cases.

Subject terms:

generalized periodontitis - enzyme therapy - mmunodeficiency - biocenosis - Medicine (General)

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Features of laboratory indicators of severe community-acquired pneumonia
Pertzeva T.A.;Avramenko I.V.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 2, Pp 24-31 (2017) Please log in to see more details
Based on data from the prospective analysis of patients with severe community-acquired... more
Features of laboratory indicators of severe community-acquired pneumonia
Medičnì Perspektivi, Vol 22, Iss 2, Pp 24-31 (2017)
Based on data from the prospective analysis of patients with severe community-acquired pneumonia over the year of observation, the article presents data on the features of laboratory indicators of the course of severe community-acquired pneumonia. Patients included in the study were hospitalized in the pulmonology department (or therapy), and in the intensive care unit of three clinical hospitals in the city of Dnipro, namely, the Dnipropetrovsk City Clinical Hospital N 6, the Dnipropetrovsk City Clinical Hospital N 2, the Dnipropetrovsk City Clinical Hospital N 16, which are the clinical bases of the SE “Dnipropetrovsk medical academy of Health Ministry of Ukraine”. In the course of studies, the dependence of the severity of patients' state on the severity of inflammatory markers and fibrosis markers was shown. The effect of the prognostic significance of the level of the enzyme TGFβ and C-reactive protein (CRP) for the evaluation of possibility of formation of long-term pathological changes after a severe community-acquired pneumonia has been examined. It was established that a high level of CRP (38.3 [11.3, 150.9] mg / L) and TGFβ (20149.1±424.0 pg/ml) in the blood plasma of patients can be considered as an additional marker of the severity of the course of community-acquired pneumonia. The results can be the basis for a more individual approach to the development of diagnostic and therapeutic programs for patients with severe community-acquired pneumonia.

Subject terms:

severe community acquired pneumonia features of pneumonia - pneumonia - severe community acquired pneumonia - features of pneumonia - Medicine (General)

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Complex treatment of generalized catarrhal gingivitis with precursors of early formation of destructive phenomena in the bone structures of periodontium
Gudaryan А.А.;Struk V.I.;Vatamanyuk N.V.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 22, Iss 2, Pp 111-118 (2017) Please log in to see more details
The article presents the results of comprehensive rehabilitation of 92 patients with g... more
Complex treatment of generalized catarrhal gingivitis with precursors of early formation of destructive phenomena in the bone structures of periodontium
Medičnì Perspektivi, Vol 22, Iss 2, Pp 111-118 (2017)
The article presents the results of comprehensive rehabilitation of 92 patients with generalized catarrhal gingivitis by creating differentiated programs for prevention and treatment of the disease, depending on the absence or presence of laboratory signs that have not been detected by X-ray, early destructive processes in the bone structures of periodontal tissues. It was revealed that appearance in gums tissue of representatives of the major periodontal bacteria is a precursor to the development of initial stage of generalized periodontitis in it. It was established that the earlier objective indicators of bone resorptive process in periodontal tissues in patients with generalized catarrhal gingivitis is an overproduction of proinflammatory cytokines IL-1.beta and TNF-alpha and the lack of anti-inflammatory cytokine IL-4.

Subject terms:

generalized catarrhal gingivitis - generalized periodontitis - microbiocenosis - mmunodeficiency - Medicine (General)

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