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Journal 'Medicni perspektivi'
Medicni perspektivi
Journal "Medicni perspektivi" (ISSN 2307-0404) publishes scientific articles devoted t... more
Journal 'Medicni perspektivi'
01/01/2018
Journal "Medicni perspektivi" (ISSN 2307-0404) publishes scientific articles devoted to topical problems of theoretical, clinical, preventive, social medicine, its history as well as lectures, interesting case reports, covering unusual cases, reviews on monographs and commemorative articles devoted to prominent scientists. Main tasks of the journal - publishing research articles with the aim to the most topical and up-to-date propagation aspects of scientific thought as for modern achievements and topical problems of domestic and foreign scientists. Journal "Medicni perspektivi" uses policy of open access of published materials. The full texts of articles have been posted on our website from 2005 (PDF). Founder: SE "Dnipropetrovsk medical academy of Health Ministry of Ukraine" . Frequency – 4 times per year. Language of publications: Ukrainian, Russian, English.

Subject terms:

110701 Allergy - 110301 Anaesthesiology - 110702 Applied Immunology (incl. Antibody Engineering - Xenotransplantation and T-cell Therapies) - 111501 Basic Pharmacology - 111202 Cancer Diagnosis - 111201 Cancer Cell Biology - 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy) - 110201 Cardiology (incl. Cardiovascular Diseases) - 110299 Cardiorespiratory Medicine and Haematology not elsewhere classified - 111703 Care for Disabled - 111601 Cell Physiology - 110704 Cellular Immunology - 111205 Chemotherapy - 110302 Clinical Chemistry (diagnostics) - 110303 Clinical Microbiology - 111502 Clinical Pharmacology and Therapeutics - 111704 Community Child Health - 110304 Dermatology - 110307 Gastroenterology and Hepatology - Health Care - 110107 Metabolic Medicine - 111403 Paediatrics - 110324 Venereology

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Journal 'Medicni perspektivi'
Medicni perspektivi
Journal "Medicni perspektivi" (ISSN 2307-0404) publishes scientific articles devoted t... more
Journal 'Medicni perspektivi'
01/01/2018
Journal "Medicni perspektivi" (ISSN 2307-0404) publishes scientific articles devoted to topical problems of theoretical, clinical, preventive, social medicine, its history as well as lectures, interesting case reports, covering unusual cases, reviews on monographs and commemorative articles devoted to prominent scientists. Main tasks of the journal - publishing research articles with the aim to the most topical and up-to-date propagation aspects of scientific thought as for modern achievements and topical problems of domestic and foreign scientists. Journal "Medicni perspektivi" uses policy of open access of published materials. The full texts of articles have been posted on our website from 2005 (PDF). Founder: SE "Dnipropetrovsk medical academy of Health Ministry of Ukraine" . Frequency – 4 times per year. Language of publications: Ukrainian, Russian, English.

Subject terms:

110701 Allergy - 110301 Anaesthesiology - 110702 Applied Immunology (incl. Antibody Engineering - Xenotransplantation and T-cell Therapies) - 111501 Basic Pharmacology - 111202 Cancer Diagnosis - 111201 Cancer Cell Biology - 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy) - 110201 Cardiology (incl. Cardiovascular Diseases) - 110299 Cardiorespiratory Medicine and Haematology not elsewhere classified - 111703 Care for Disabled - 111601 Cell Physiology - 110704 Cellular Immunology - 111205 Chemotherapy - 110302 Clinical Chemistry (diagnostics) - 110303 Clinical Microbiology - 111502 Clinical Pharmacology and Therapeutics - 111704 Community Child Health - 110304 Dermatology - 110307 Gastroenterology and Hepatology - Health Care - 110107 Metabolic Medicine - 111403 Paediatrics - 110324 Venereology

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Journal 'Medicni perspektivi' 2018 Vol. XXIII N 1, part 2
Journal Medicni perspektivi
Journal "Medicni perspektivi" 2018 Vol. XXIII N 1, part 2 Published 2018.03.28 ISSN 23... more
Journal 'Medicni perspektivi' 2018 Vol. XXIII N 1, part 2
01/01/2018
Journal "Medicni perspektivi" 2018 Vol. XXIII N 1, part 2 Published 2018.03.28 ISSN 2307-0404 http://medpers.dsma.dp.ua/en/

Subject terms:

110301 Anaesthesiology - 110201 Cardiology (incl. Cardiovascular Diseases) - 110299 Cardiorespiratory Medicine and Haematology not elsewhere classified - 110303 Clinical Microbiology - Diseases - 111706 Epidemiology - 111707 Family Care - 110307 Gastroenterology and Hepatology - 110202 Haematology - Health Care - 111709 Health Care Administration - 111712 Health Promotion - 110706 Immunogenetics (incl. Genetic Immunology) - 111403 Paediatrics - 110314 Orthopaedics

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Journal 'Medicni perspektivi' 2018 Vol. XXIII N 1, part 2
Journal Medicni perspektivi
Journal "Medicni perspektivi" 2018 Vol. XXIII N 1, part 2 Published 2018.03.28 ISSN 23... more
Journal 'Medicni perspektivi' 2018 Vol. XXIII N 1, part 2
01/01/2018
Journal "Medicni perspektivi" 2018 Vol. XXIII N 1, part 2 Published 2018.03.28 ISSN 2307-0404 http://medpers.dsma.dp.ua/en/

Subject terms:

110301 Anaesthesiology - 110201 Cardiology (incl. Cardiovascular Diseases) - 110299 Cardiorespiratory Medicine and Haematology not elsewhere classified - 110303 Clinical Microbiology - Diseases - 111706 Epidemiology - 111707 Family Care - 110307 Gastroenterology and Hepatology - 110202 Haematology - Health Care - 111709 Health Care Administration - 111712 Health Promotion - 110706 Immunogenetics (incl. Genetic Immunology) - 111403 Paediatrics - 110314 Orthopaedics

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Journal 'Medicni perspektivi' 2018 Vol. XXIII N 1, part 1
Journal Medicni perspektivi
Journal "Medicni perspektivi" 2018 Vol. XXIII N 1, part 1 Published 2018.03.28 ISSN 23... more
Journal 'Medicni perspektivi' 2018 Vol. XXIII N 1, part 1
01/01/2018
Journal "Medicni perspektivi" 2018 Vol. XXIII N 1, part 1 Published 2018.03.28 ISSN 2307-0404 http://medpers.dsma.dp.ua/en/

Subject terms:

110701 Allergy - 110301 Anaesthesiology - 110703 Autoimmunity - Biomarkers - 110201 Cardiology (incl. Cardiovascular Diseases) - 110299 Cardiorespiratory Medicine and Haematology not elsewhere classified - 110303 Clinical Microbiology - 110304 Dermatology - Diseases - 111102 Dietetics and Nutrigenomics - 110306 Endocrinology - 110307 Gastroenterology and Hepatology - 110706 Immunogenetics (incl. Genetic Immunology) - 110799 Immunology not elsewhere classified - 110801 Medical Bacteriology - 110899 Medical Microbiology not elsewhere classified - 110804 Medical Virology - 110312 Nephrology and Urology - 110904 Neurology and Neuromuscular Diseases - 111403 Paediatrics - 110316 Pathology (excl. Oral Pathology) - 110203 Respiratory Diseases - 110323 Surgery - 110708 Transplantation Immunology

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Journal 'Medicni perspektivi' 2018 Vol. XXIII N 1, part 1
Journal Medicni perspektivi
Journal "Medicni perspektivi" 2018 Vol. XXIII N 1, part 1 Published 2018.03.28 ISSN 23... more
Journal 'Medicni perspektivi' 2018 Vol. XXIII N 1, part 1
01/01/2018
Journal "Medicni perspektivi" 2018 Vol. XXIII N 1, part 1 Published 2018.03.28 ISSN 2307-0404 http://medpers.dsma.dp.ua/en/

Subject terms:

110701 Allergy - 110301 Anaesthesiology - 110703 Autoimmunity - Biomarkers - 110201 Cardiology (incl. Cardiovascular Diseases) - 110299 Cardiorespiratory Medicine and Haematology not elsewhere classified - 110303 Clinical Microbiology - 110304 Dermatology - Diseases - 111102 Dietetics and Nutrigenomics - 110306 Endocrinology - 110307 Gastroenterology and Hepatology - 110706 Immunogenetics (incl. Genetic Immunology) - 110799 Immunology not elsewhere classified - 110801 Medical Bacteriology - 110899 Medical Microbiology not elsewhere classified - 110804 Medical Virology - 110312 Nephrology and Urology - 110904 Neurology and Neuromuscular Diseases - 111403 Paediatrics - 110316 Pathology (excl. Oral Pathology) - 110203 Respiratory Diseases - 110323 Surgery - 110708 Transplantation Immunology

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Journal 'Medicni perspektivi' 2018 Vol. XXIII N 1
Journal Medicni perspektivi
Journal "Medicni perspektivi" 2018 Vol. XXIII N 1 Published 2017.03.06 ISSN 2307-0404 ... more
Journal 'Medicni perspektivi' 2018 Vol. XXIII N 1
01/01/2018
Journal "Medicni perspektivi" 2018 Vol. XXIII N 1 Published 2017.03.06 ISSN 2307-0404 http://medpers.dsma.dp.ua/en/

Subject terms:

110701 Allergy - 110301 Anaesthesiology - 110703 Autoimmunity - 110201 Cardiology (incl. Cardiovascular Diseases) - 110299 Cardiorespiratory Medicine and Haematology not elsewhere classified - 110303 Clinical Microbiology - 110304 Dermatology - Diseases - 110308 Geriatrics and Gerontology - 110202 Haematology - Health Care - 111299 Oncology and Carcinogenesis not elsewhere classified - 110314 Orthopaedics - 111403 Paediatrics - 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified - 111208 Radiation Therapy - 110324 Venereology

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Journal 'Medicni perspektivi' 2018 Vol. XXIII N 1
Journal Medicni perspektivi
Journal "Medicni perspektivi" 2018 Vol. XXIII N 1 Published 2017.03.06 ISSN 2307-0404 ... more
Journal 'Medicni perspektivi' 2018 Vol. XXIII N 1
01/01/2018
Journal "Medicni perspektivi" 2018 Vol. XXIII N 1 Published 2017.03.06 ISSN 2307-0404 http://medpers.dsma.dp.ua/en/

Subject terms:

110701 Allergy - 110301 Anaesthesiology - 110703 Autoimmunity - 110201 Cardiology (incl. Cardiovascular Diseases) - 110299 Cardiorespiratory Medicine and Haematology not elsewhere classified - 110303 Clinical Microbiology - 110304 Dermatology - Diseases - 110308 Geriatrics and Gerontology - 110202 Haematology - Health Care - 111299 Oncology and Carcinogenesis not elsewhere classified - 110314 Orthopaedics - 111403 Paediatrics - 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified - 111208 Radiation Therapy - 110324 Venereology

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Journal 'Medicni perspektivi' 2017 Vol. XXII N 4
Journal Medicni perspektivi
Journal "Medicni perspektivi" 2017 Vol. XXII N 3 Published 2017.12.06 ISSN 2307-0404 h... more
Journal 'Medicni perspektivi' 2017 Vol. XXII N 4
01/01/2018
Journal "Medicni perspektivi" 2017 Vol. XXII N 3 Published 2017.12.06 ISSN 2307-0404 http://medpers.dsma.dp.ua/en/

Subject terms:

110701 Allergy - 110301 Anaesthesiology - 111202 Cancer Diagnosis - 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy) - 110201 Cardiology (incl. Cardiovascular Diseases) - 110299 Cardiorespiratory Medicine and Haematology not elsewhere classified - 110303 Clinical Microbiology - 110304 Dermatology - Diseases - 110306 Endocrinology - 110202 Haematology - 111709 Health Care Administration - 110104 Medical Biochemistry: Lipids - 110107 Metabolic Medicine - 110904 Neurology and Neuromuscular Diseases - 110312 Nephrology and Urology - 110505 Oral Medicine and Pathology - 111403 Paediatrics - 110324 Venereology

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Journal 'Medicni perspektivi' 2017 Vol. XXII N 4
Journal Medicni perspektivi
Journal "Medicni perspektivi" 2017 Vol. XXII N 3 Published 2017.12.06 ISSN 2307-0404 h... more
Journal 'Medicni perspektivi' 2017 Vol. XXII N 4
01/01/2018
Journal "Medicni perspektivi" 2017 Vol. XXII N 3 Published 2017.12.06 ISSN 2307-0404 http://medpers.dsma.dp.ua/en/

Subject terms:

110701 Allergy - 110301 Anaesthesiology - 111202 Cancer Diagnosis - 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy) - 110201 Cardiology (incl. Cardiovascular Diseases) - 110299 Cardiorespiratory Medicine and Haematology not elsewhere classified - 110303 Clinical Microbiology - 110304 Dermatology - Diseases - 110306 Endocrinology - 110202 Haematology - 111709 Health Care Administration - 110104 Medical Biochemistry: Lipids - 110107 Metabolic Medicine - 110904 Neurology and Neuromuscular Diseases - 110312 Nephrology and Urology - 110505 Oral Medicine and Pathology - 111403 Paediatrics - 110324 Venereology

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Journal 'Medicni perspektivi' 2017 Vol. XXII N 3
Journal Medicni perspektivi
Journal "Medicni perspektivi" 2017 Vol. XXII N 3 Published 2017.10.11 ISSN 2307-0404 h... more
Journal 'Medicni perspektivi' 2017 Vol. XXII N 3
01/01/2018
Journal "Medicni perspektivi" 2017 Vol. XXII N 3 Published 2017.10.11 ISSN 2307-0404 http://medpers.dsma.dp.ua/en/

Subject terms:

110701 Allergy - 110301 Anaesthesiology - 110703 Autoimmunity - 111202 Cancer Diagnosis - 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy) - 110299 Cardiorespiratory Medicine and Haematology not elsewhere classified - 111704 Community Child Health - 110502 Dental Therapeutics - Pharmacology and Toxicology - 110304 Dermatology - Diseases - 111706 Epidemiology - 110307 Gastroenterology and Hepatology - 110308 Geriatrics and Gerontology - Health Care - 111709 Health Care Administration - 110801 Medical Bacteriology - 110312 Nephrology and Urology - 110904 Neurology and Neuromuscular Diseases - 111301 Ophthalmology - 110314 Orthopaedics - 111403 Paediatrics - 111499 Paediatrics and Reproductive Medicine not elsewhere classified - 111504 Pharmaceutical Sciences - 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified - 110317 Physiotherapy - 111716 Preventive Medicine - 110203 Respiratory Diseases - 110323 Surgery - 111506 Toxicology (incl. Clinical Toxicology)

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Journal 'Medicni perspektivi' 2017 Vol. XXII N 3
Journal Medicni perspektivi
Journal "Medicni perspektivi" 2017 Vol. XXII N 3 Published 2017.10.11 ISSN 2307-0404 h... more
Journal 'Medicni perspektivi' 2017 Vol. XXII N 3
01/01/2018
Journal "Medicni perspektivi" 2017 Vol. XXII N 3 Published 2017.10.11 ISSN 2307-0404 http://medpers.dsma.dp.ua/en/

Subject terms:

110701 Allergy - 110301 Anaesthesiology - 110703 Autoimmunity - 111202 Cancer Diagnosis - 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy) - 110299 Cardiorespiratory Medicine and Haematology not elsewhere classified - 111704 Community Child Health - 110502 Dental Therapeutics - Pharmacology and Toxicology - 110304 Dermatology - Diseases - 111706 Epidemiology - 110307 Gastroenterology and Hepatology - 110308 Geriatrics and Gerontology - Health Care - 111709 Health Care Administration - 110801 Medical Bacteriology - 110312 Nephrology and Urology - 110904 Neurology and Neuromuscular Diseases - 111301 Ophthalmology - 110314 Orthopaedics - 111403 Paediatrics - 111499 Paediatrics and Reproductive Medicine not elsewhere classified - 111504 Pharmaceutical Sciences - 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified - 110317 Physiotherapy - 111716 Preventive Medicine - 110203 Respiratory Diseases - 110323 Surgery - 111506 Toxicology (incl. Clinical Toxicology)

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Journal 'Medicni perspektivi' 2017 Vol. XXII N 2
Journal Medicni perspektivi
Journal "Medicni perspektivi" 2017 Vol. XXII N 2 Published 2017.06.29 ISSN 2307-0404 h... more
Journal 'Medicni perspektivi' 2017 Vol. XXII N 2
01/01/2018
Journal "Medicni perspektivi" 2017 Vol. XXII N 2 Published 2017.06.29 ISSN 2307-0404 http://medpers.dsma.dp.ua/en/

Subject terms:

110701 Allergy - 110301 Anaesthesiology - 110703 Autoimmunity - 111202 Cancer Diagnosis - 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy) - 110201 Cardiology (incl. Cardiovascular Diseases) - 110299 Cardiorespiratory Medicine and Haematology not elsewhere classified - 110303 Clinical Microbiology - 110501 Dental Materials and Equipment - 110502 Dental Therapeutics - Pharmacology and Toxicology - 110599 Dentistry not elsewhere classified - 110304 Dermatology - Diseases - 110307 Gastroenterology and Hepatology - 110308 Geriatrics and Gerontology - 111206 Haematological Tumours - 110202 Haematology - Health Care - 111709 Health Care Administration - 111710 Health Counselling - 110799 Immunology not elsewhere classified - 110311 Medical Genetics (excl. Cancer Genetics) - 110899 Medical Microbiology not elsewhere classified - 110312 Nephrology and Urology - 110904 Neurology and Neuromuscular Diseases - 111301 Ophthalmology - 110314 Orthopaedics - 111403 Paediatrics - Pathogenesis

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Journal 'Medicni perspektivi' 2017 Vol. XXII N 2
Journal Medicni perspektivi
Journal "Medicni perspektivi" 2017 Vol. XXII N 1 Published 2017.04.04 ISSN 2307-0404 h... more
Journal 'Medicni perspektivi' 2017 Vol. XXII N 2
01/01/2018
Journal "Medicni perspektivi" 2017 Vol. XXII N 1 Published 2017.04.04 ISSN 2307-0404 http://medpers.dsma.dp.ua/en/

Subject terms:

110701 Allergy - 110301 Anaesthesiology - 110703 Autoimmunity - 111202 Cancer Diagnosis - 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy) - 110201 Cardiology (incl. Cardiovascular Diseases) - 110299 Cardiorespiratory Medicine and Haematology not elsewhere classified - 110303 Clinical Microbiology - 110501 Dental Materials and Equipment - 110502 Dental Therapeutics - Pharmacology and Toxicology - 110599 Dentistry not elsewhere classified - 110304 Dermatology - Diseases - 110307 Gastroenterology and Hepatology - 110308 Geriatrics and Gerontology - 111206 Haematological Tumours - 110202 Haematology - Health Care - 111709 Health Care Administration - 111710 Health Counselling - 110799 Immunology not elsewhere classified - 110311 Medical Genetics (excl. Cancer Genetics) - 110899 Medical Microbiology not elsewhere classified - 110312 Nephrology and Urology - 110904 Neurology and Neuromuscular Diseases - 111301 Ophthalmology - 110314 Orthopaedics - 111403 Paediatrics - Pathogenesis

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Journal 'Medicni perspektivi' 2017 N1
Journal Medicni perspektivi
Journal "Medicni perspektivi" 2017 N1 more
Journal 'Medicni perspektivi' 2017 N1
01/01/2018
Journal "Medicni perspektivi" 2017 N1

Subject terms:

110701 Allergy - 110301 Anaesthesiology - 110703 Autoimmunity - 111501 Basic Pharmacology - 111202 Cancer Diagnosis - 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy) - 111601 Cell Physiology - 110704 Cellular Immunology - 111502 Clinical Pharmacology and Therapeutics - 111503 Clinical Pharmacy and Pharmacy Practice - 110399 Clinical Sciences not elsewhere classified - 111704 Community Child Health

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Journal 'Medicni perspektivi' 2017 Vol. XXII N 1
Journal Medicni perspektivi
Journal "Medicni perspektivi" 2017 Vol. XXII N 1 Published 2017.04.04 ISSN 2307-0404 h... more
Journal 'Medicni perspektivi' 2017 Vol. XXII N 1
01/01/2018
Journal "Medicni perspektivi" 2017 Vol. XXII N 1 Published 2017.04.04 ISSN 2307-0404 http://medpers.dsma.dp.ua/en/

Subject terms:

110701 Allergy - 110301 Anaesthesiology - 110703 Autoimmunity - 111501 Basic Pharmacology - 111202 Cancer Diagnosis - 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy) - 111601 Cell Physiology - 110704 Cellular Immunology - 111502 Clinical Pharmacology and Therapeutics - 111503 Clinical Pharmacy and Pharmacy Practice - 110399 Clinical Sciences not elsewhere classified - 111704 Community Child Health

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Journal 'Medicni perspektivi' 2017 Vol. XXII N 1
Journal Medicni perspektivi
Journal "Medicni perspektivi" 2017 Vol. XXII N 1 ISSN 2307-0404 Published 2017.04.04 h... more
Journal 'Medicni perspektivi' 2017 Vol. XXII N 1
01/01/2018
Journal "Medicni perspektivi" 2017 Vol. XXII N 1 ISSN 2307-0404 Published 2017.04.04 http://medpers.dsma.dp.ua/en/

Subject terms:

110701 Allergy - 110301 Anaesthesiology - 110703 Autoimmunity - 111501 Basic Pharmacology - 111202 Cancer Diagnosis - 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy) - 111601 Cell Physiology - 110704 Cellular Immunology - 111502 Clinical Pharmacology and Therapeutics - 111503 Clinical Pharmacy and Pharmacy Practice - 110399 Clinical Sciences not elsewhere classified - 111704 Community Child Health

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Medičnì Perspektivi
Academic Journal Academic Journal | 01/01/2015 Please log in to see more details
Medičnì Perspektivi
01/01/2015

Subject terms:

social medicine - theoretical medicine - clinical medicine - preventive medicine - Medicine (General) - R5-920

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Medičnì Perspektivi
Academic Journal Academic Journal | 09/02/2015 Please log in to see more details
Medičnì Perspektivi
09/02/2015

Subject terms:

social medicine - theoretical medicine - clinical medicine - preventive medicine - Medicine (General) - R5-920

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Directory of Open Access Journals

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Influence of the course of type 1 diabetes on the left ventricular myocardial geometry and intracardiac hemodynamic.
K. I. Moshenets
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 23, Iss 4, Pp 31-40 (2019) Please log in to see more details
The aim of the study was to examine changes in left ventricle (LV) geometry and to eva... more
Influence of the course of type 1 diabetes on the left ventricular myocardial geometry and intracardiac hemodynamic.
Medičnì Perspektivi, Vol 23, Iss 4, Pp 31-40 (2019)
The aim of the study was to examine changes in left ventricle (LV) geometry and to evaluate the systolic and diastolic function of LV in patients with type 1 diabetes mellitus (T1DM) depending on the course of the disease. Materials and methods. 63 patients with T1DM were examined. The mean age was 31.5 (24.0, 39.0) years, the duration of the disease was 11.0 (5.0, 18.0) years. Laboratory tests: C-peptide, HbA1c, blood creatinine, first morning urinary albumin excretion (UAE), glomerular filtration rate (GFR) according to the formula CKD-EPI were made. Long-term monitoring of blood glucose levels during 6 days was conducted by using the CGMS system. Transthoracic echocardiography and tissue Doppler imaging were used. Patients were divided into groups: Group 1 – HbA1c≤7.0% (n = 21), Group 2 – HbA1c> 7.0% (n = 42). 10 sex- and age-matched healthy controls were included. Results. Patients with DM 1 had significantly higher indices of the LV mass index (LVMI), LV posterior wall thickness, interventricular septal excursion and left ventricular posterior wall excursion (p <0.05). Hypoglycemic episodes lead to thickening of the interventricular septum and LV posterior wall thickness, increase of LV end-systolic volume, decrease of ejection fraction, and prolongation of isovolumteric relaxation time (p <0.05). Diastolic dysfunction with impaired relaxation (grade I) was 18 inpatients with DM 1 (28.57%) without significant differences between the 1-st and 2-nd groups. Concentric remodeling of LV occurs in 16 (76.2%) patients of group 1 and in 27 (64.29%) of group 2. Eccentric hypertrophy of LV is determined in 1 (4.76%) patient of group 1 and in 5 (11.9%) of group 2, respectively, and only in 9.52% patients with T1DM. Conclusions. Patients with DM 1 have signs of structural and geometric reconstruction and diastolic dysfunction. Hypoglycemia is a significant factor leading to the formation of LV hypertrophy, as well as to decrease both of diastolic and systolic function of the myocardium.

Subject terms:

diabetes mellitus type 1 - diastolic dysfunction - left ventricular hypertrophy - Medicine (General) - R5-920

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Rationale for the choice of operations in esophageal leiomyoma.
V. V. Vasylkivskyi;V. G. Getman
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 23, Iss 4, Pp 75-81 (2019) Please log in to see more details
Operations on the esophagus occupy an important place in the surgery of the gastrointe... more
Rationale for the choice of operations in esophageal leiomyoma.
Medičnì Perspektivi, Vol 23, Iss 4, Pp 75-81 (2019)
Operations on the esophagus occupy an important place in the surgery of the gastrointestinal tract, since this organ passes through three anatomical regions: the neck, thoracic and abdominal cavity. The main pathologies for surgical interventions arecongenital malformations, injuries, foreign bodies, burns and scarry strictures, neuromuscular diseases of the esophagus, hernia of the esophagus and reflux esophagitis, diverticula, acquired fistula, esophageal cancer, benign tumors and cysts. For the majority of these conditions clear recommendations on diagnosis and treatment have been developed. In the literature, there is no consensus on indications for conservative or surgical treatment of patients with esophageal leiomyoma and the type of surgical intervention: 1) resection of the esophagus 2) removal of the tumor with part of the wall; 3) enucleation of the tumor; 4) endoscopic removal. Mortality after resection of the esophagus or its wall with plastic is 13%, and after enucleation of leiomyoma – 2%. In our clinical study, the analysis of the performed operations on patients with leiomyoma of the esophagus was performed. The aim – to make a retrospective analysis of different types of surgical interventions in patients with esophageal leiomyoma performed in the thoracic departments of the National Cancer Institute, Kiev City Clinical Cancer Center, Kiev Clinical Hospital N 17, Zhytomyr Regional Hospital, Vinnitsa Regional Hospital. Retrospective evaluation of 66 patients with morphologically confirmed esophageal leiomyoma was made. The following types of imagining were performed in patients: radiological examination of esophagus with solution of barium sulphate and radiography, computed tomography of the chest (CTc), computed tomography angiography (CTA), magnetic resonance contrast-enhanced imaging (MRI TO). Instrumental methods: esophagogastroduodenoscopy (EGD) with biopsy, endoscopic ultrasound, endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNA). The type of surgical interventions: proximal gastrectomy (n=3); Garlock operation (n=2); Lewis operation (n=3), resection of the tumor with part of the esophageal wall (n=6); tumor enucleation (n=52). Complications after operations in the early period: postoperative bleeding - the source is not identified, failure of the esophageal wall seam. In the late postoperative period – esophageal pleural fistula in two patients and esophageal stenosis in one patient. Indication for removal of leiomyomas: severity of symptoms, tumor size more than 5 cm, multiple leiomyomas, transition onto the stomach, patient's persistent desire, increase of volume in dynamics, changes in mucosa over the mass. Indications for resection options for surgery: adhesion of the tumor with the mucosa for more than three centimeters, the inability to exclude the malignant process, the giant esophageal leiomyoma with the transition onto the stomach. Patients who underwent non-surgical operations had a shorter postoperative hospital stay, fewer complications and a better quality of life. According to our results, preoperative biopsy with intact mucosa is not informative, but also does not increase the number of perforations.

Subject terms:

leiomyoma - submucosal tumor - esophagus - benign tumors - Medicine (General) - R5-920

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Features of the treatment of elderly patients with coronary heart disease at the stages of 1990, 2010 and 2017 examinations.
I. S. Shapovalenko
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 23, Iss 4, Pp 20-30 (2019) Please log in to see more details
The purpose of the work is to determine the characteristics of prescription, adherence... more
Features of the treatment of elderly patients with coronary heart disease at the stages of 1990, 2010 and 2017 examinations.
Medičnì Perspektivi, Vol 23, Iss 4, Pp 20-30 (2019)
The purpose of the work is to determine the characteristics of prescription, adherence to treatment and the effect of certain classes of drugs used for the treatment of cardiovascular diseases on the life expectancy of elderly patients with ischemic heart disease (IHD). 517 case histories of patients aged 60-87 (–91) years old, born in 1925-1957 with IHD were analyzed. All the examined were first hospitalized in the hospital and later were observed with the main diagnosis of coronary artery disease: stable exertional angina I-IV FC. Further observation of the patients lasted from 3 to 25 years (average observation period 10 years), until reaching the endpoint or until the last observation in 2017. The patient’s death was chosen as the endpoint, on the basis of which the life expectancy index (determined by the year / age of death) was studied. It has been shown, that therapeutic regimens for the elderly patients with coronary artery disease meet current standards for the treatment of coronary artery disease at the stages of 1990, 2010 and 2017. Patients' adherence to therapy was 82.4%. According to the data obtained, the association of taking certain classes of drugs with the life expectancy of patients was: ACE inhibitors increase life expectancy by 7 years, acetylsalicylic acid (ASA) - by 4 years, statins and β-blockers - by 2 years. The most effective combinations for treating people with IHD that affect life expectancy are: combinations of ASC, statins and ACE inhibitors - survival up to 80.14±3.16 years, ASA, statins and Ca-channel blockers - survival up to 80±1.71 years, ASC, statins and β-blockers - survival to 79.3±4.24 years, ASA and ACE inhibitors - survival to 79.59±3.83 years.

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coronary heart disease - elderly patients - features of treatment - Medicine (General) - R5-920

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Influence of psychophysiological features of the 3-d course students on their training at the department of pathological physiology SE "DMA".
V. V. Koldunov;G. A. Klopotskyi;Ju. V. Kozlova;G. S. Kaniuka;G. F. Starushk...
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 23, Iss 4, Pp 11-15 (2019) Please log in to see more details
The article presents the results of the individual psychophysiological features analys... more
Influence of psychophysiological features of the 3-d course students on their training at the department of pathological physiology SE "DMA".
Medičnì Perspektivi, Vol 23, Iss 4, Pp 11-15 (2019)
The article presents the results of the individual psychophysiological features analysis of the 3-d course students of the Dentistry Faculty, who have completed studying pathological physiology. The obtained data were compared with the results of the complex exam and the results of the licensing exam STEP-1. As a result, it was found that the psychophysiological indicators of students affect on learning performance. The main psychological differences between successful and unsuccessful students are in the intellectual and emotional-will spheres. Therefore, conducting psychophysiological testing among students and familiarizing them with the results obtained makes it possible for future doctors to take into account their personal and psychophysiological characteristics not only during the training period, but also in their professional activities. Such information, on the one hand, may induce many students to work on themselves, and on the other - not to fall into illusions. Further research in this direction and carrying out correlations of the obtained results will allow to find and eliminate the causes of unsatisfactory students’ studying. Work in this direction will contribute to the development of fundamentally new teaching methods in accordance with the requirements of time and scientific-technical progress.

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psychophysiological state - higher medical education - exam - pathological physiology - Medicine (General) - R5-920

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Influence of gel bentonite on physiological indicators of the white laboratory mice.
V. P. Shyrobokov;V. A. Poniatovskyi;О. Р. Yavorovskyi;D. S. Jankowskyi;G. S...
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 23, Iss 4, Pp 4-11 (2019) Please log in to see more details
The evaluation of the effect of lifelong usage of sodium form of gel bentonite on some... more
Influence of gel bentonite on physiological indicators of the white laboratory mice.
Medičnì Perspektivi, Vol 23, Iss 4, Pp 4-11 (2019)
The evaluation of the effect of lifelong usage of sodium form of gel bentonite on some physiological parameters of mice (body weight, feed and water intake, general condition, change in coordination of movements, state of wool, fertility and mortality) was performed on 110 white laboratory mice (BALB / c line). This experimental study was carried out in two replicates. To accomplish this task, the mice were divided into two groups: control – the animals were on a standard diet, and experimental – they used water with the addition of sodium form of bentonite gel (0.5-1%). It was found that prolonged intake of bentonite gel by laboratory animals neither led to an excessive increase in their weight (the weight gain of the experimental group did not differ statistically significantly from the control group, p≤0.05), nor did it cause acute or chronic intoxication. It is also shown that the constant use of bentonite has a positive effect on the organism of experimental mice, which is expressed in the decrease of animal mortality, increase of life expectancy and pronounced positive effect on fertility functions (increase in the number of offspring). Based on the obtained data it can be assumed that the continuous intake of bentonite by the animal organism is one of the factors of their microbiome improvement, which affects on a plenty of physiological functions, including animals reproduction. It is possible that smectite sorbents also enrich the body of mice by certain essential mineral elements (silicon, etc.) and has cytomucoprotective properties concerning the mucous membranes of the macroorganism.

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white laboratory mice - bentonite gel - Medicine (General) - R5-920

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Management of patients with pulmonary arterial hypertension against systemic sclerodermia (part 2).
O. O. Khaniukov;Ye. D. Yehudina;O. S. Kalashnykova
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 23, Iss 4, Pp 40-51 (2019) Please log in to see more details
Pulmonary arterial hypertension (PAH) is a serious condi­tion caused by the damage of ... more
Management of patients with pulmonary arterial hypertension against systemic sclerodermia (part 2).
Medičnì Perspektivi, Vol 23, Iss 4, Pp 40-51 (2019)
Pulmonary arterial hypertension (PAH) is a serious condi­tion caused by the damage of the small pulmonary vessels, leading to the increase of pulmonary artery pressure, pulmonary vascular resistance, development of right ventricular failure and death. PAH is one of the actual problems of modern medicine due to low survival rate, rapid disability of the patients and a high cost of treatment. PAH is one of the leading causes of death in systemic sclerodermia (SSD). PAH associated with scleroderma is a unique phenotype combining the manifestations of both SSD and PAH, the pathogenetic mechanisms of which modify the clinical picture and the course of these conditions. Timely diagnosis and treatment of PAH show significant effect on survival rates, however, early detection of PAH is still difficult in SSD due to several factors. The main causes are restriction of modern screening methods and polyorganic involvement in SSD. In comparison with other subgroups of PAH the patients with SSD-PAH poorly answer to the specific PAH therapy. SSD-PAH, along with idiopathic pulmonary hypertension (IPAH), belongs to group I of pulmonary hypertension classification and according to modern consensus has a similar pathogenesis and clinical picture, however, differences in the response to therapy are observed in these groups, that indicates the role of other pathobiological mechanisms. Recent investigations explain these differences by such factors as autoimmune and inflammatory responses, more severe vascular remodeling and direct myocardial damage in the SSD. Drug therapy of PH in SSD is similar to that in IPAH and includes prostaglandins, endothelin receptor antagonists, calcium channel blockers, which are prescribed in cases of a positive vasoreactive test, PDE-5 inhibitors. In this literature review we showed traditional and new methods of PAH treatment and their relevance to SSD-PAH in accordance with randomized clinical trials.

Subject terms:

pulmonary arterial hypertension - systemic scleroderma - pharmacological treatment of pulmonary hypertension - Medicine (General) - R5-920

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