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Medičnì Perspektivi
Academic Journal Academic Journal | 09/02/2015 Please log in to see more details
Medičnì Perspektivi
09/02/2015

Subject terms:

social medicine - theoretical medicine - clinical medicine - preventive medicine - Medicine (General) - R5-920

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Analysis of the level of expression of pancytokeratins in epithelial and granulocellular tumors of the ovaries
Savchenko O.A.;Shponka I.S.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 23, Iss 2, Pp 21-25 (2018) Please log in to see more details
Differential diagnosis of ovarian neoplasms is carried out among groups of epithelial ... more
Analysis of the level of expression of pancytokeratins in epithelial and granulocellular tumors of the ovaries
Medičnì Perspektivi, Vol 23, Iss 2, Pp 21-25 (2018)
Differential diagnosis of ovarian neoplasms is carried out among groups of epithelial and granulocellular tumors and remains an actual problem of oncogynecology. In general, epithelial tumors occur (up to 60%), but granulocellular cell tumors account for up to 5% of all ovarian neoplasia. Materials and methods. A retrospective study of 43 observations of ovarian tumor lesions over the period of January-December 2017 was conducted in the work. The aim of the study was to analyze the complex of morphological and immunohistochemical characteristics of Cytokeratin, Pan AE1 / AE3 - negative phenotypes and Cytokeratin, Pan AE1 / AE3 - positive phenotypes of ovarian neoplasia to improve diagnostic algorithms. Results. The phenotype of epithelial ovarian tumors in 100% of observations corresponds to pancytokeratin Cytokeratin, Pan AE1 / AE3 "+", in its turn the phenotype of granulocellular tumors basically responded to expression of the Cytokeratin marker, Pan AE1 / AE3 "-" in 62.5%; and the variant in the part of the cells "+" / "-" Cytokeratin, Pan AE1 / AE3 was found in 37.5% of granulocellular tumors, regardless of their malignant potential. Thus, granulocellular tumors have variable expression of the Cytokeratin marker, Pan AE1 / AE3 and require the inclusion of other diagnostic IGH markers in the primary panel.

Subject terms:

epithelial ovarian tumors - granulo-cellular tumors - Medicine (General) - R5-920

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Clinincal variants of trancient neurological deficit in patients with the neck osteochondrosis
Zozulia I.S.;Nesukai V.G.
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 23, Iss 2, Pp 78-84 (2018) Please log in to see more details
With the purpose of studing frequency and variability of clinical symptoms there were ... more
Clinincal variants of trancient neurological deficit in patients with the neck osteochondrosis
Medičnì Perspektivi, Vol 23, Iss 2, Pp 78-84 (2018)
With the purpose of studing frequency and variability of clinical symptoms there were observed 130 patients after transient ischemic attack (TIA) in a vertebrobasillar pool (VBP) on a background of neck osteochondrosis, verified from MRI, CT data or sciagraphies of the neck portion of the spine with functional tests. The analysis did not include patients with the signs of acute or past chronic stroke. After systematization of complaints and symptoms four clinical syndromes were selected: ophthalmic (OPS), vestibuloatactic (VAS), cochleovestibular (CVS) and local neurological symptoms (LNS) among which VAS and CVS appeared in 27.9 and 31.2% of young patients, respectively, and in 33.3 and 27.3% of the elderly ones. In patients with OPS, visual impairment was more frequent (in 63.6% of patients) and predominantly in women with a frequency of 62.5%, in patients with VAS - dizziness, which occurred in 74.2% of women and 90.0% of men, with CVS - noise in the ear (68.4%) without a gender difference, in patients with LNS the frequency of hemiparesis/hemiplegia was 34.5% and prevailed in patients of the older age group (50.0 versus 15.4% in young patients).

Subject terms:

vertebral basilar system - transient ischemic attacks - neck osteochondrosis - clinical syndromes - Medicine (General) - R5-920

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Analysis of the level of expression of pancytokeratins in epithelial and granulocellular tumors of the ovaries.
O. A. Savchenko;I. S. Shponka
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 23, Iss 2, Pp 21-25 (2018) Please log in to see more details
Differential diagnosis of ovarian neoplasms is carried out among groups of epithelial ... more
Analysis of the level of expression of pancytokeratins in epithelial and granulocellular tumors of the ovaries.
Medičnì Perspektivi, Vol 23, Iss 2, Pp 21-25 (2018)
Differential diagnosis of ovarian neoplasms is carried out among groups of epithelial and granulocellular tumors and remains an actual problem of oncogynecology. In general, epithelial tumors occur (up to 60%), but granulocellular cell tumors account for up to 5% of all ovarian neoplasia. Materials and methods. A retrospective study of 43 observations of ovarian tumor lesions over the period of January-December 2017 was conducted in the work. The aim of the study was to analyze the complex of morphological and immunohistochemical characteristics of Cytokeratin, Pan AE1 / AE3 - negative phenotypes and Cytokeratin, Pan AE1 / AE3 - positive phenotypes of ovarian neoplasia to improve diagnostic algorithms. Results. The phenotype of epithelial ovarian tumors in 100% of observations corresponds to pancytokeratin Cytokeratin, Pan AE1 / AE3 "+", in its turn the phenotype of granulocellular tumors basically responded to expression of the Cytokeratin marker, Pan AE1 / AE3 "-" in 62.5%; and the variant in the part of the cells "+" / "-" Cytokeratin, Pan AE1 / AE3 was found in 37.5% of granulocellular tumors, regardless of their malignant potential. Thus, granulocellular tumors have variable expression of the Cytokeratin marker, Pan AE1 / AE3 and require the inclusion of other diagnostic IGH markers in the primary panel.

Subject terms:

epithelial ovarian tumors - granulo-cellular tumors - immunohistochemistry - Medicine (General) - R5-920

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Squamous cell carcinoma of unknown primary localization: isolated lesion of cervical lymph nodes.
O. V. Poslavska;I. S. Shponka
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 23, Iss 2, Pp 13-20 (2018) Please log in to see more details
Cancers of unknown primary localization (CUPL) are a heterogeneous group of metastatic... more
Squamous cell carcinoma of unknown primary localization: isolated lesion of cervical lymph nodes.
Medičnì Perspektivi, Vol 23, Iss 2, Pp 13-20 (2018)
Cancers of unknown primary localization (CUPL) are a heterogeneous group of metastatic neoplasias for which a standardized diagnostic examination did not determine the primary localization of the origin. In 5% of histological form of CUPL is squamous cell carcinoma, which, in the case of an isolated lesion of the cervical lymph nodes is treated as a "favorable phenotype". Tactics of treatment of such a CUPL is suggested in both primary local squamous cell carcinoma (SCC) of the, head and neck with regional lymph nodes involvement (T1-3N1-3M0) and in 25% -30% of patients leads to a 5-years survival rate. This calls for the use of an immunohistochemical method for the accurate verification of the histological form of an isolated metastasis of the cervical lymph nodes and use of the appropriate therapy. In the work 62 samples of isolated lesions of the cervical lymph nodes with carcinomas without another established primary localization for the period 2015-2017 were investigated. The control group consisted of 12 samples of SCC of the head and neck of the known localizations. The immunohistochemical panel of markers included Cytokeratin Pan, Vimentin, CD45, S100, Cytokeratin HMW, Cytokeratin 7, Cytokeratin 20, p63, TTF1. The parameters of the areas, perimeters and “roundness” of the nucleus were determined in the ImageJ pro­gram. The aim of the study was to investigate the complex of morphological, morphometric and immunohistochemical characteristics of SCC without primary localization with isolated lesion of the cervical lymph nodes, in comparison with other histological forms and control group of SCC of the head and neck of the known localizations to improve diagnostic algorithms. A difference in the distribution of histological forms for all CUPL with isolated lesion of the cervical lymph nodes was determined in the predominance of SCC, in comparison with the general distribution of histological forms for all CUPL. Similarity of morphometric parameters of metastatic SCC of subgroup 1 (phenotype of Cytokeratin, Pan AE1 / AE3 (+) / Cytokeratin HMW (+) / p63 (+) / Cytokeratin 20 (-) / TTF1 (-) / Vimentin (- / +) / Cytokeratin 7 (- / +)) with samples of the control group of SCC of the head and neck of known localizations. The es­tablished decrease in the size and "roundness ratio" of the nuclei of the SCC cells is a reflection of the weighting of cellular atypia and correlates with the polymorphism of the nuclei and decrease in the degree of differentiation of the SCC.

Subject terms:

CUT - squamous cell carcinoma - lymph nodes of the neck - ImageJ - Medicine (General) - R5-920

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Comparative evaluation of genetic risk models of reproductive disorders caused by MTHFR, MTRR, MTR1 gene polymorphism.
Z. І. Rossokha;S. P. Kyriachenko;N. G. Gorovenko
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 23, Iss 2, Pp 85-91 (2018) Please log in to see more details
The scientific literature presents contradictory data about influence of folate metabo... more
Comparative evaluation of genetic risk models of reproductive disorders caused by MTHFR, MTRR, MTR1 gene polymorphism.
Medičnì Perspektivi, Vol 23, Iss 2, Pp 85-91 (2018)
The scientific literature presents contradictory data about influence of folate metabolism genes polymorphism on development of risk of reproductive disorders. The aim of the study was to determine the role of MTHFR, MTRR, MTR1 gene polymorphism in the development of reproductive disorders by evaluation of genetic risk models of inheritance. 658 patients with reproductive disorders from all Ukrainian regions were examined. The data from population studies presented in the online resource (1000 genomes) served as comparison group. There were no reliable risk models for polymorphic variants of MTHFR gene. We identified 3 and 4 significant inheritance models for MTRR and MTR1 genes respectively. The best inheritance models were the dominant model for MTRR gene and the additive model for MTR1 gene. The polymorphic variants frequencies of the studied genes did not differ among men and women. Further analyse is necessary for evaluation of genetic polymorphism and intergenic interactions influence on reproductive disorders risk, taking into account folate metabolism indices and exogenous factors.

Subject terms:

inheritance models - reproductive disorders - polymorphic variants - MTHFR - MTRR - MTR1 - genes - Medicine (General) - R5-920

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Neurochemical and behavioral processes in gerontogenesis in conditions of experimental hyperglycemia.
O. Rodynskyi;K. Basysta;L. Guz
Academic Journal Academic Journal | Medičnì Perspektivi, Vol 23, Iss 2, Pp 4-13 (2018) Please log in to see more details
Many researchers are increasingly interested in the relation between diabetes and diab... more
Neurochemical and behavioral processes in gerontogenesis in conditions of experimental hyperglycemia.
Medičnì Perspektivi, Vol 23, Iss 2, Pp 4-13 (2018)
Many researchers are increasingly interested in the relation between diabetes and diabetic encephalopathy. At the moment, there are various experiments where this issue is considered. But despite prolonged studying, it is impossible to investigate this problem to the end. Cognitive deficit in hyperglycemia is also connected with aging. In the aging processes as in hyperglycemia the same pathogenetic factors play a role in the aging of the brain. It is also necessary to deeply analyze the neurochemical processes occurring in the brain in diabetes mellitus. The high incidence of complications is caused by tissue metabolism impairment in hyperglycemia. The study of neurochemical bases of brain activity is one of the leading and promising directions in the modern neuropathology. Scientists of different countries are searching for neurospecific damage markers of the brain substance in hyperglycemia.

Subject terms:

experimental diabetes - experimental hyperglycemia - alloxan - diabetic encephalopathy - glial fibrillary acidic protein - Medicine (General) - R5-920

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